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Rigshospitalet - en del af Københavns Universitetshospital
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Iron chelation therapy in thalassemia major: a systematic review with meta-analyses of 1520 patients included on randomized clinical trials

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Increased risk of ALL among premature infants is not explained by increased prevalence of pre-leukemic cell clones

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Aurelio Maggio
  • Aldo Filosa
  • Angela Vitrano
  • Giuseppina Aloj
  • Antonis Kattamis
  • Adriana Ceci
  • Suthat Fucharoen
  • Paolo Cianciulli
  • Robert W Grady
  • Luciano Prossomariti
  • John B Porter
  • Angela Iacono
  • Maria Domenica Cappellini
  • Fedele Bonifazi
  • Filippo Cassarà
  • Paul Harmatz
  • John Wood
  • Christian Gluud
Vis graf over relationer
The effectiveness of deferoxamine (DFO), deferiprone (DFP), or deferasirox (DFX) in thalassemia major was assessed. Outcomes were reported as means±SD, mean differences with 95% CI, or standardized mean differences. Statistical heterogeneity was tested using χ2 (Q) and I2. Sources of bias and Grading of Recommendations Assessment, Development and Evaluation system (GRADE) were considered. Overall, 1520 patients were included. Only 7.4% of trials were free of bias. Overall measurements suggest low trial quality (GRADE). The meta-analysis suggests lower final liver iron concentrations during associated versus monotherapy treatment (p
OriginalsprogEngelsk
TidsskriftBlood Cells, Molecules and Diseases
Vol/bind47
Udgave nummer3
Sider (fra-til)166-75
Antal sider10
ISSN1079-9796
DOI
StatusUdgivet - 2011

ID: 33171878