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Invasive candidiasis

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Harvard

Pappas, PG, Lionakis, MS, Arendrup, MC, Ostrosky-Zeichner, L & Kullberg, BJ 2018, 'Invasive candidiasis', Nature reviews. Disease primers, bind 4, s. 18026. https://doi.org/10.1038/nrdp.2018.26

APA

Pappas, P. G., Lionakis, M. S., Arendrup, M. C., Ostrosky-Zeichner, L., & Kullberg, B. J. (2018). Invasive candidiasis. Nature reviews. Disease primers, 4, 18026. https://doi.org/10.1038/nrdp.2018.26

CBE

Pappas PG, Lionakis MS, Arendrup MC, Ostrosky-Zeichner L, Kullberg BJ. 2018. Invasive candidiasis. Nature reviews. Disease primers. 4:18026. https://doi.org/10.1038/nrdp.2018.26

MLA

Vancouver

Pappas PG, Lionakis MS, Arendrup MC, Ostrosky-Zeichner L, Kullberg BJ. Invasive candidiasis. Nature reviews. Disease primers. 2018 maj 11;4:18026. https://doi.org/10.1038/nrdp.2018.26

Author

Pappas, Peter G ; Lionakis, Michail S ; Arendrup, Maiken Cavling ; Ostrosky-Zeichner, Luis ; Kullberg, Bart Jan. / Invasive candidiasis. I: Nature reviews. Disease primers. 2018 ; Bind 4. s. 18026.

Bibtex

@article{680129502d5049bb9397854e710b4f3b,
title = "Invasive candidiasis",
abstract = "Invasive candidiasis is an important health-care-associated fungal infection that can be caused by several Candida spp.; the most common species is Candida albicans, but the prevalence of these organisms varies considerably depending on geographical location. The spectrum of disease of invasive candidiasis ranges from minimally symptomatic candidaemia to fulminant sepsis with an associated mortality exceeding 70%. Candida spp. are common commensal organisms in the skin and gut microbiota, and disruptions in the cutaneous and gastrointestinal barriers (for example, owing to gastrointestinal perforation) promote invasive disease. A deeper understanding of specific Candida spp. virulence factors, host immune response and host susceptibility at the genetic level has led to key insights into the development of early intervention strategies and vaccine candidates. The early diagnosis of invasive candidiasis is challenging but key to the effective management, and the development of rapid molecular diagnostics could improve the ability to intervene rapidly and potentially reduce mortality. First-line drugs, including echinocandins and azoles, are effective, but the emergence of antifungal resistance, especially among Candida glabrata, is a matter of concern and underscores the need to administer antifungal medications in a judicious manner, avoiding overuse when possible. A newly described pathogen, Candida auris, is an emerging multidrug-resistant organism that poses a global threat.",
author = "Pappas, {Peter G} and Lionakis, {Michail S} and Arendrup, {Maiken Cavling} and Luis Ostrosky-Zeichner and Kullberg, {Bart Jan}",
year = "2018",
month = may,
day = "11",
doi = "10.1038/nrdp.2018.26",
language = "English",
volume = "4",
pages = "18026",
journal = "Nature Reviews Disease Primers",
issn = "2056-676X",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Invasive candidiasis

AU - Pappas, Peter G

AU - Lionakis, Michail S

AU - Arendrup, Maiken Cavling

AU - Ostrosky-Zeichner, Luis

AU - Kullberg, Bart Jan

PY - 2018/5/11

Y1 - 2018/5/11

N2 - Invasive candidiasis is an important health-care-associated fungal infection that can be caused by several Candida spp.; the most common species is Candida albicans, but the prevalence of these organisms varies considerably depending on geographical location. The spectrum of disease of invasive candidiasis ranges from minimally symptomatic candidaemia to fulminant sepsis with an associated mortality exceeding 70%. Candida spp. are common commensal organisms in the skin and gut microbiota, and disruptions in the cutaneous and gastrointestinal barriers (for example, owing to gastrointestinal perforation) promote invasive disease. A deeper understanding of specific Candida spp. virulence factors, host immune response and host susceptibility at the genetic level has led to key insights into the development of early intervention strategies and vaccine candidates. The early diagnosis of invasive candidiasis is challenging but key to the effective management, and the development of rapid molecular diagnostics could improve the ability to intervene rapidly and potentially reduce mortality. First-line drugs, including echinocandins and azoles, are effective, but the emergence of antifungal resistance, especially among Candida glabrata, is a matter of concern and underscores the need to administer antifungal medications in a judicious manner, avoiding overuse when possible. A newly described pathogen, Candida auris, is an emerging multidrug-resistant organism that poses a global threat.

AB - Invasive candidiasis is an important health-care-associated fungal infection that can be caused by several Candida spp.; the most common species is Candida albicans, but the prevalence of these organisms varies considerably depending on geographical location. The spectrum of disease of invasive candidiasis ranges from minimally symptomatic candidaemia to fulminant sepsis with an associated mortality exceeding 70%. Candida spp. are common commensal organisms in the skin and gut microbiota, and disruptions in the cutaneous and gastrointestinal barriers (for example, owing to gastrointestinal perforation) promote invasive disease. A deeper understanding of specific Candida spp. virulence factors, host immune response and host susceptibility at the genetic level has led to key insights into the development of early intervention strategies and vaccine candidates. The early diagnosis of invasive candidiasis is challenging but key to the effective management, and the development of rapid molecular diagnostics could improve the ability to intervene rapidly and potentially reduce mortality. First-line drugs, including echinocandins and azoles, are effective, but the emergence of antifungal resistance, especially among Candida glabrata, is a matter of concern and underscores the need to administer antifungal medications in a judicious manner, avoiding overuse when possible. A newly described pathogen, Candida auris, is an emerging multidrug-resistant organism that poses a global threat.

U2 - 10.1038/nrdp.2018.26

DO - 10.1038/nrdp.2018.26

M3 - Review

C2 - 29749387

VL - 4

SP - 18026

JO - Nature Reviews Disease Primers

JF - Nature Reviews Disease Primers

SN - 2056-676X

ER -

ID: 56271350