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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Intra-arterial nimodipine for cerebral vasospasm after subarachnoid haemorrhage: Influence on clinical course and predictors of clinical outcome

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Non-aneurysmal subarachnoid hemorrhage: When is a second angiography indicated?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Treatment of intracranial aneurysms. Reconstruction of the parent artery with flow-diverting (Silk) stent

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Long-Term Follow-Up and Predictors of Functional Outcome after Surgery for Spinal Meningiomas: A Population-Based Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Lumbar puncture position influences intracranial pressure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Risk factors for need of reoperation in bilateral chronic subdural haematomas

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Development and external validation of a clinical prediction model for functional impairment after intracranial tumor surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Endovascular treatment for cerebral venous sinus thrombosis - a single center study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Intra-arterial nimodipine (IAN) has shown a promising effect on cerebral vasospasm (CV) after aneurysmal subarachnoid haemorrhage. At our institution, Rigshospitalet, IAN treatment has been used since 2009, but the short- and long-term clinical efficacy of IAN has not yet been assessed. The purpose was to evaluate the efficacy and clinical outcome of IAN treatment of symptomatic CV, and to assess the predictors of clinical outcome. Medical records of 25 patients undergoing a total of 41 IAN treatment sessions were retrospectively reviewed. Data on angiographic results, blood-flow velocities and the clinical condition before and after the IAN treatment were recorded. Predictors of the clinical outcome were assessed with a linear regression model. Positive angiographic response was achieved in 95.1% of 41 IAN treatment sessions. Flow-velocity measurements showed no relationship with angiographic responses of IAN. The immediate clinical improvement was observed in three patients (12%). Five patients (20%) had a favourable outcome at discharge and at three-month follow-up; 10 patients (40%) had a moderate to poor outcome; and the rest (40%) died. Increased number of affected vessels and number of procedures carried out per patient, and a trend toward an increased delay time from symptomatic CV to confirming angiographic CV and thus instituting IAN treatment predicted the poor clinical outcome. IAN treatment appears to be effective in reversing angiographic CV. However, it is not always effective in reversing clinical deterioration, as several other factors including treatment delay affect the clinical course.

OriginalsprogEngelsk
TidsskriftNeuroradiology
Vol/bind29
Udgave nummer1
Sider (fra-til)72-81
Antal sider10
ISSN1971-4009
DOI
StatusUdgivet - feb. 2016

ID: 49631430