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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

International multicenter tool to predict the risk of four or more tumor-positive axillary lymph nodes in breast cancer patients with sentinel node macrometastases

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Tuomo J Meretoja
  • R A Audisio
  • P S Heikkilä
  • R Bori
  • I Sejben
  • P Regitnig
  • G Luschin-Ebengreuth
  • J Zgajnar
  • A Perhavec
  • B Gazic
  • G Lázár
  • T Takács
  • B Kővári
  • Z A Saidan
  • R M Nadeem
  • I Castellano
  • A Sapino
  • S Bianchi
  • V Vezzosi
  • E Barranger
  • R Lousquy
  • R Arisio
  • M P Foschini
  • S Imoto
  • H Kamma
  • T F Tvedskov
  • M-B Jensen
  • G Cserni
  • M H K Leidenius
Vis graf over relationer
Recently, many centers have omitted routine axillary lymph node dissection (ALND) after metastatic sentinel node biopsy in breast cancer due to a growing body of literature. However, existing guidelines of adjuvant treatment planning are strongly based on axillary nodal stage. In this study, we aim to develop a novel international multicenter predictive tool to estimate a patient-specific risk of having four or more tumor-positive axillary lymph nodes (ALN) in patients with macrometastatic sentinel node(s) (SN). A series of 675 patients with macrometastatic SN and completion ALND from five European centers were analyzed by logistic regression analysis. A multivariate predictive model was created and validated internally by 367 additional patients and then externally by 760 additional patients from eight different centers. All statistical tests were two-sided. Prevalence of four or more tumor-positive ALN in each center's series (P = 0.010), number of metastatic SNs (P
OriginalsprogEngelsk
TidsskriftBreast Cancer Research and Treatment
Vol/bind138
Udgave nummer3
Sider (fra-til)817-27
Antal sider11
ISSN0167-6806
DOI
StatusUdgivet - apr. 2013

ID: 43149495