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Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin

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Harvard

Woetmann, A, Alhede, M, Dabelsteen, S, Bjarnsholt, T, Rybtke, M, Nastasi, C, Krejsgaard, T, Andersen, MH, Bonefeld, CM, Geisler, C, Givskov, M & Odum, N 2018, 'Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin' Oncotarget, bind 9, nr. 28, s. 19481-19489. https://doi.org/10.18632/oncotarget.24603

APA

CBE

Woetmann A, Alhede M, Dabelsteen S, Bjarnsholt T, Rybtke M, Nastasi C, Krejsgaard T, Andersen MH, Bonefeld CM, Geisler C, Givskov M, Odum N. 2018. Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin. Oncotarget. 9(28):19481-19489. https://doi.org/10.18632/oncotarget.24603

MLA

Vancouver

Author

Woetmann, Anders ; Alhede, Morten ; Dabelsteen, Sally ; Bjarnsholt, Thomas ; Rybtke, Morten ; Nastasi, Claudia ; Krejsgaard, Thorbjørn ; Andersen, Mads Hald ; Bonefeld, Charlotte M ; Geisler, Carsten ; Givskov, Michael ; Odum, Niels. / Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin. I: Oncotarget. 2018 ; Bind 9, Nr. 28. s. 19481-19489.

Bibtex

@article{4f6670720f6e444dba9506b11b7c0cf9,
title = "Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin",
abstract = "Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ, (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S. aureus. Thus, we provide novel evidence that IL-26 is an anti-microbial peptide produced by T cells in response to SE. Accordingly, we propose that IL-26 producing T cells take part in the innate immune response to SE producing S. aureus and thus play a novel role in the primary innate immune defense in addition to their classical role in adaptive immunity.",
author = "Anders Woetmann and Morten Alhede and Sally Dabelsteen and Thomas Bjarnsholt and Morten Rybtke and Claudia Nastasi and Thorbj{\o}rn Krejsgaard and Andersen, {Mads Hald} and Bonefeld, {Charlotte M} and Carsten Geisler and Michael Givskov and Niels Odum",
year = "2018",
month = "4",
day = "13",
doi = "10.18632/oncotarget.24603",
language = "English",
volume = "9",
pages = "19481--19489",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "28",

}

RIS

TY - JOUR

T1 - Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin

AU - Woetmann, Anders

AU - Alhede, Morten

AU - Dabelsteen, Sally

AU - Bjarnsholt, Thomas

AU - Rybtke, Morten

AU - Nastasi, Claudia

AU - Krejsgaard, Thorbjørn

AU - Andersen, Mads Hald

AU - Bonefeld, Charlotte M

AU - Geisler, Carsten

AU - Givskov, Michael

AU - Odum, Niels

PY - 2018/4/13

Y1 - 2018/4/13

N2 - Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ, (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S. aureus. Thus, we provide novel evidence that IL-26 is an anti-microbial peptide produced by T cells in response to SE. Accordingly, we propose that IL-26 producing T cells take part in the innate immune response to SE producing S. aureus and thus play a novel role in the primary innate immune defense in addition to their classical role in adaptive immunity.

AB - Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ, (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S. aureus. Thus, we provide novel evidence that IL-26 is an anti-microbial peptide produced by T cells in response to SE. Accordingly, we propose that IL-26 producing T cells take part in the innate immune response to SE producing S. aureus and thus play a novel role in the primary innate immune defense in addition to their classical role in adaptive immunity.

U2 - 10.18632/oncotarget.24603

DO - 10.18632/oncotarget.24603

M3 - Journal article

VL - 9

SP - 19481

EP - 19489

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 28

ER -

ID: 55803472