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Intergenerational effects of maternal post-traumatic stress disorder on offspring epigenetic patterns and cortisol levels

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Harvard

Hjort, L, Rushiti, F, Wang, SJ, Fransquet, P, P Krasniqi, S, I Çarkaxhiu, S, Arifaj, D, Xhemaili, VD, Salihu, M, A Leku, N & Ryan, J 2021, 'Intergenerational effects of maternal post-traumatic stress disorder on offspring epigenetic patterns and cortisol levels', Epigenomics, bind 13, nr. 12, s. 967-980. https://doi.org/10.2217/epi-2021-0015

APA

Hjort, L., Rushiti, F., Wang, S. J., Fransquet, P., P Krasniqi, S., I Çarkaxhiu, S., Arifaj, D., Xhemaili, V. D., Salihu, M., A Leku, N., & Ryan, J. (2021). Intergenerational effects of maternal post-traumatic stress disorder on offspring epigenetic patterns and cortisol levels. Epigenomics, 13(12), 967-980. https://doi.org/10.2217/epi-2021-0015

CBE

Hjort L, Rushiti F, Wang SJ, Fransquet P, P Krasniqi S, I Çarkaxhiu S, Arifaj D, Xhemaili VD, Salihu M, A Leku N, Ryan J. 2021. Intergenerational effects of maternal post-traumatic stress disorder on offspring epigenetic patterns and cortisol levels. Epigenomics. 13(12):967-980. https://doi.org/10.2217/epi-2021-0015

MLA

Vancouver

Author

Hjort, Line ; Rushiti, Feride ; Wang, Shr Jie ; Fransquet, Peter ; P Krasniqi, Sebahate ; I Çarkaxhiu, Selvi ; Arifaj, Dafina ; Xhemaili, Vjosa Devaja ; Salihu, Mimoza ; A Leku, Nazmie ; Ryan, Joanne. / Intergenerational effects of maternal post-traumatic stress disorder on offspring epigenetic patterns and cortisol levels. I: Epigenomics. 2021 ; Bind 13, Nr. 12. s. 967-980.

Bibtex

@article{8518444ab2844028a68c453529ceb4df,
title = "Intergenerational effects of maternal post-traumatic stress disorder on offspring epigenetic patterns and cortisol levels",
abstract = "Aim: To investigate the association between maternal post-traumatic stress disorder (PTSD) during pregnancy and offspring DNA methylation and cortisol levels. Materials & methods: Blood genome-wide DNA methylation and cortisol was measured in the youngest child of 117 women who experienced sexual violence/torture during the Kosovo war. Results: Seventy-two percent of women had PTSD symptoms during pregnancy. Their children had higher cortisol levels and differential methylation at candidate genes (NR3C1, HTR3A and BNDF). No methylation differences reached epigenome-wide corrected significance levels. Conclusion: Identifying the biological processes whereby the negative effects of trauma are passed across generations and defining groups at high risk is a key step to breaking the intergenerational transmission of the effects of mental disorders.",
keywords = "cortisol, DNA methylation, epigenetics, intergenerational, maternal stress, offspring, PTSD",
author = "Line Hjort and Feride Rushiti and Wang, {Shr Jie} and Peter Fransquet and {P Krasniqi}, Sebahate and {I {\c C}arkaxhiu}, Selvi and Dafina Arifaj and Xhemaili, {Vjosa Devaja} and Mimoza Salihu and {A Leku}, Nazmie and Joanne Ryan",
note = "Publisher Copyright: {\textcopyright} 2021 ",
year = "2021",
month = jun,
doi = "10.2217/epi-2021-0015",
language = "English",
volume = "13",
pages = "967--980",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "Future Medicine Ltd",
number = "12",

}

RIS

TY - JOUR

T1 - Intergenerational effects of maternal post-traumatic stress disorder on offspring epigenetic patterns and cortisol levels

AU - Hjort, Line

AU - Rushiti, Feride

AU - Wang, Shr Jie

AU - Fransquet, Peter

AU - P Krasniqi, Sebahate

AU - I Çarkaxhiu, Selvi

AU - Arifaj, Dafina

AU - Xhemaili, Vjosa Devaja

AU - Salihu, Mimoza

AU - A Leku, Nazmie

AU - Ryan, Joanne

N1 - Publisher Copyright: © 2021

PY - 2021/6

Y1 - 2021/6

N2 - Aim: To investigate the association between maternal post-traumatic stress disorder (PTSD) during pregnancy and offspring DNA methylation and cortisol levels. Materials & methods: Blood genome-wide DNA methylation and cortisol was measured in the youngest child of 117 women who experienced sexual violence/torture during the Kosovo war. Results: Seventy-two percent of women had PTSD symptoms during pregnancy. Their children had higher cortisol levels and differential methylation at candidate genes (NR3C1, HTR3A and BNDF). No methylation differences reached epigenome-wide corrected significance levels. Conclusion: Identifying the biological processes whereby the negative effects of trauma are passed across generations and defining groups at high risk is a key step to breaking the intergenerational transmission of the effects of mental disorders.

AB - Aim: To investigate the association between maternal post-traumatic stress disorder (PTSD) during pregnancy and offspring DNA methylation and cortisol levels. Materials & methods: Blood genome-wide DNA methylation and cortisol was measured in the youngest child of 117 women who experienced sexual violence/torture during the Kosovo war. Results: Seventy-two percent of women had PTSD symptoms during pregnancy. Their children had higher cortisol levels and differential methylation at candidate genes (NR3C1, HTR3A and BNDF). No methylation differences reached epigenome-wide corrected significance levels. Conclusion: Identifying the biological processes whereby the negative effects of trauma are passed across generations and defining groups at high risk is a key step to breaking the intergenerational transmission of the effects of mental disorders.

KW - cortisol

KW - DNA methylation

KW - epigenetics

KW - intergenerational

KW - maternal stress

KW - offspring

KW - PTSD

UR - http://www.scopus.com/inward/record.url?scp=85106526832&partnerID=8YFLogxK

U2 - 10.2217/epi-2021-0015

DO - 10.2217/epi-2021-0015

M3 - Journal article

C2 - 33993712

AN - SCOPUS:85106526832

VL - 13

SP - 967

EP - 980

JO - Epigenomics

JF - Epigenomics

SN - 1750-1911

IS - 12

ER -

ID: 69222844