Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genome-wide association study identifies 16 genomic regions associated with circulating cytokines at birth

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Habitual sleep disturbances and migraine: a Mendelian randomization study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Functional gene networks reveal distinct mechanisms segregating in migraine families

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
  • Thomas Mears Werge (Medlem af forfattergruppering)
  • Thomas Folkmann Hansen
Vis graf over relationer

Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.

OriginalsprogEngelsk
TidsskriftNature Communications
Vol/bind10
Udgave nummer1
Sider (fra-til)2548
ISSN2041-1723
DOI
StatusUdgivet - 11 jun. 2019

ID: 59084457