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Increasing incidence and survival in oral cancer: a nationwide Danish study from 1980 to 2014

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@article{5236d264ccb9497c8a66398ce4ed0760,
title = "Increasing incidence and survival in oral cancer: a nationwide Danish study from 1980 to 2014",
abstract = "BACKGROUND: Oral carcinomas (OCs) make up a significant proportion of head and neck carcinomas (HNCs) and are an important cause of morbidity and mortality globally. The purpose of this population-based study was to determine trends in incidence and survival in OC in the Danish population from 1980 to 2014.MATERIAL AND METHODS: This study covered all patients registered in the nationwide Danish cancer registry (DCR) in the period 1980-2014. Age-adjusted incidence rate (AAIR) per 100,000 and annual percentage change (APC) were evaluated. Also, 5-year overall survival (OS) was calculated with Cox regression analysis in relation to location, gender, age, and calendar year at diagnosis.RESULTS: Altogether, 8299 patients with oral cancer were identified, 5062 (61{\%}) of whom were males and 3237 (39{\%}) were females. The median age at diagnosis was 63 years. The AAIR of patients with OC increased from 1.9 per 100,000 in 1980 to 3.5 per 100,000 in 2014, and we observed a significant increase in 5-year OS of 12{\%} points (a relative increase of 38{\%}) from the period 1980-1984 to 2005-2009. Women were found to have a better prognosis than men.CONCLUSIONS: We found an unexpected increase in the age-standardized incidence of OC during the last 30 years in Denmark, and also an improvement in survival. The 5-year OS was significantly better in recent years even when we adjusted the analysis for relevant covariates.",
keywords = "Journal Article",
author = "Karnov, {Kirstine Schmidt} and Christian Gr{\o}nh{\o}j and Jensen, {David Hebbelstrup} and Irene Wessel and Charabi, {Birgitte Wittenborg} and Lena Specht and Andreas Kjaer and {von Buchwald}, Christian",
year = "2017",
month = "9",
doi = "10.1080/0284186X.2017.1307516",
language = "English",
volume = "56",
pages = "1204--1209",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "Informa Healthcare",
number = "9",

}

RIS

TY - JOUR

T1 - Increasing incidence and survival in oral cancer

T2 - a nationwide Danish study from 1980 to 2014

AU - Karnov, Kirstine Schmidt

AU - Grønhøj, Christian

AU - Jensen, David Hebbelstrup

AU - Wessel, Irene

AU - Charabi, Birgitte Wittenborg

AU - Specht, Lena

AU - Kjaer, Andreas

AU - von Buchwald, Christian

PY - 2017/9

Y1 - 2017/9

N2 - BACKGROUND: Oral carcinomas (OCs) make up a significant proportion of head and neck carcinomas (HNCs) and are an important cause of morbidity and mortality globally. The purpose of this population-based study was to determine trends in incidence and survival in OC in the Danish population from 1980 to 2014.MATERIAL AND METHODS: This study covered all patients registered in the nationwide Danish cancer registry (DCR) in the period 1980-2014. Age-adjusted incidence rate (AAIR) per 100,000 and annual percentage change (APC) were evaluated. Also, 5-year overall survival (OS) was calculated with Cox regression analysis in relation to location, gender, age, and calendar year at diagnosis.RESULTS: Altogether, 8299 patients with oral cancer were identified, 5062 (61%) of whom were males and 3237 (39%) were females. The median age at diagnosis was 63 years. The AAIR of patients with OC increased from 1.9 per 100,000 in 1980 to 3.5 per 100,000 in 2014, and we observed a significant increase in 5-year OS of 12% points (a relative increase of 38%) from the period 1980-1984 to 2005-2009. Women were found to have a better prognosis than men.CONCLUSIONS: We found an unexpected increase in the age-standardized incidence of OC during the last 30 years in Denmark, and also an improvement in survival. The 5-year OS was significantly better in recent years even when we adjusted the analysis for relevant covariates.

AB - BACKGROUND: Oral carcinomas (OCs) make up a significant proportion of head and neck carcinomas (HNCs) and are an important cause of morbidity and mortality globally. The purpose of this population-based study was to determine trends in incidence and survival in OC in the Danish population from 1980 to 2014.MATERIAL AND METHODS: This study covered all patients registered in the nationwide Danish cancer registry (DCR) in the period 1980-2014. Age-adjusted incidence rate (AAIR) per 100,000 and annual percentage change (APC) were evaluated. Also, 5-year overall survival (OS) was calculated with Cox regression analysis in relation to location, gender, age, and calendar year at diagnosis.RESULTS: Altogether, 8299 patients with oral cancer were identified, 5062 (61%) of whom were males and 3237 (39%) were females. The median age at diagnosis was 63 years. The AAIR of patients with OC increased from 1.9 per 100,000 in 1980 to 3.5 per 100,000 in 2014, and we observed a significant increase in 5-year OS of 12% points (a relative increase of 38%) from the period 1980-1984 to 2005-2009. Women were found to have a better prognosis than men.CONCLUSIONS: We found an unexpected increase in the age-standardized incidence of OC during the last 30 years in Denmark, and also an improvement in survival. The 5-year OS was significantly better in recent years even when we adjusted the analysis for relevant covariates.

KW - Journal Article

U2 - 10.1080/0284186X.2017.1307516

DO - 10.1080/0284186X.2017.1307516

M3 - Journal article

VL - 56

SP - 1204

EP - 1209

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 9

ER -

ID: 51770096