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Increased Risk of Gallstone Disease Following Colectomy for Ulcerative Colitis

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Harvard

Mark-Christensen, A, Brandsborg, S, Laurberg, S, Johansen, N, Pachler, JH, Thorlacius-Ussing, O, Kjær, MD, Qvist, N, Preisler, L, Hillingsø, J, Rosenberg, J & Jepsen, P 2017, 'Increased Risk of Gallstone Disease Following Colectomy for Ulcerative Colitis', The American journal of gastroenterology, bind 112, nr. 3, s. 473-478. https://doi.org/10.1038/ajg.2016.564

APA

Mark-Christensen, A., Brandsborg, S., Laurberg, S., Johansen, N., Pachler, J. H., Thorlacius-Ussing, O., Kjær, M. D., Qvist, N., Preisler, L., Hillingsø, J., Rosenberg, J., & Jepsen, P. (2017). Increased Risk of Gallstone Disease Following Colectomy for Ulcerative Colitis. The American journal of gastroenterology, 112(3), 473-478. https://doi.org/10.1038/ajg.2016.564

CBE

Mark-Christensen A, Brandsborg S, Laurberg S, Johansen N, Pachler JH, Thorlacius-Ussing O, Kjær MD, Qvist N, Preisler L, Hillingsø J, Rosenberg J, Jepsen P. 2017. Increased Risk of Gallstone Disease Following Colectomy for Ulcerative Colitis. The American journal of gastroenterology. 112(3):473-478. https://doi.org/10.1038/ajg.2016.564

MLA

Vancouver

Mark-Christensen A, Brandsborg S, Laurberg S, Johansen N, Pachler JH, Thorlacius-Ussing O o.a. Increased Risk of Gallstone Disease Following Colectomy for Ulcerative Colitis. The American journal of gastroenterology. 2017 mar 1;112(3):473-478. https://doi.org/10.1038/ajg.2016.564

Author

Mark-Christensen, Anders ; Brandsborg, Søren ; Laurberg, Søren ; Johansen, Niels ; Pachler, Jørn Helmut ; Thorlacius-Ussing, Ole ; Kjær, Mie Dilling ; Qvist, Niels ; Preisler, Louise ; Hillingsø, Jens ; Rosenberg, Jacob ; Jepsen, Peter. / Increased Risk of Gallstone Disease Following Colectomy for Ulcerative Colitis. I: The American journal of gastroenterology. 2017 ; Bind 112, Nr. 3. s. 473-478.

Bibtex

@article{d9b42f2259ba4eaf9b33df1aeb90b690,
title = "Increased Risk of Gallstone Disease Following Colectomy for Ulcerative Colitis",
abstract = "OBJECTIVES: Biochemical studies suggest that patients who have had a colectomy or restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) are at an increased risk of developing gallstone disease, but epidemiological studies are lacking. We evaluated the risk of gallstone disease following colectomy and IPAA.METHODS: Individuals who had a colectomy were identified from a national cohort of patients with ulcerative colitis (UC), and controls without colectomy were sampled from within the same cohort, matching on gender, calendar year, and year of birth. We used Cox regression to examine the effect of colectomy on the hazard rates of gallstone disease and cholecystectomy, adjusting for alcoholism, stroke, chronic obstructive pulmonary disease, cancer, cardiac disease, diabetes mellitus, hypothyroidism, hyperlipidemia, cirrhosis, obesity, renal failure, and transient ischemic attacks. The effect of an IPAA was determined for patients who had colectomy by including the procedure as a time-dependent variable.RESULTS: We identified 4548 patients and matched these to 44 372 controls without colectomy. During a median follow-up of 11.9 years, 1963 patients were hospitalized for gallstone disease. Patients who had a colectomy were at an increased risk (adjusted hazard ratio (HR)=1.63 (1.39-1.91)), and sensitivity analyses of the risk of undergoing cholecystectomy revealed a similar association (adjusted HR=1.55 (1.22-1.98)). An IPAA did not affect the risk of developing gallstones among patients who had a colectomy (adjusted HR=1.03 (0.77-1.37)).CONCLUSION: The risk of gallstone disease increases following colectomy for UC.Am J Gastroenterol advance online publication, 24 January 2017; doi:10.1038/ajg.2016.564.",
author = "Anders Mark-Christensen and S{\o}ren Brandsborg and S{\o}ren Laurberg and Niels Johansen and Pachler, {J{\o}rn Helmut} and Ole Thorlacius-Ussing and Kj{\ae}r, {Mie Dilling} and Niels Qvist and Louise Preisler and Jens Hillings{\o} and Jacob Rosenberg and Peter Jepsen",
year = "2017",
month = mar,
day = "1",
doi = "10.1038/ajg.2016.564",
language = "English",
volume = "112",
pages = "473--478",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "3",

}

RIS

TY - JOUR

T1 - Increased Risk of Gallstone Disease Following Colectomy for Ulcerative Colitis

AU - Mark-Christensen, Anders

AU - Brandsborg, Søren

AU - Laurberg, Søren

AU - Johansen, Niels

AU - Pachler, Jørn Helmut

AU - Thorlacius-Ussing, Ole

AU - Kjær, Mie Dilling

AU - Qvist, Niels

AU - Preisler, Louise

AU - Hillingsø, Jens

AU - Rosenberg, Jacob

AU - Jepsen, Peter

PY - 2017/3/1

Y1 - 2017/3/1

N2 - OBJECTIVES: Biochemical studies suggest that patients who have had a colectomy or restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) are at an increased risk of developing gallstone disease, but epidemiological studies are lacking. We evaluated the risk of gallstone disease following colectomy and IPAA.METHODS: Individuals who had a colectomy were identified from a national cohort of patients with ulcerative colitis (UC), and controls without colectomy were sampled from within the same cohort, matching on gender, calendar year, and year of birth. We used Cox regression to examine the effect of colectomy on the hazard rates of gallstone disease and cholecystectomy, adjusting for alcoholism, stroke, chronic obstructive pulmonary disease, cancer, cardiac disease, diabetes mellitus, hypothyroidism, hyperlipidemia, cirrhosis, obesity, renal failure, and transient ischemic attacks. The effect of an IPAA was determined for patients who had colectomy by including the procedure as a time-dependent variable.RESULTS: We identified 4548 patients and matched these to 44 372 controls without colectomy. During a median follow-up of 11.9 years, 1963 patients were hospitalized for gallstone disease. Patients who had a colectomy were at an increased risk (adjusted hazard ratio (HR)=1.63 (1.39-1.91)), and sensitivity analyses of the risk of undergoing cholecystectomy revealed a similar association (adjusted HR=1.55 (1.22-1.98)). An IPAA did not affect the risk of developing gallstones among patients who had a colectomy (adjusted HR=1.03 (0.77-1.37)).CONCLUSION: The risk of gallstone disease increases following colectomy for UC.Am J Gastroenterol advance online publication, 24 January 2017; doi:10.1038/ajg.2016.564.

AB - OBJECTIVES: Biochemical studies suggest that patients who have had a colectomy or restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) are at an increased risk of developing gallstone disease, but epidemiological studies are lacking. We evaluated the risk of gallstone disease following colectomy and IPAA.METHODS: Individuals who had a colectomy were identified from a national cohort of patients with ulcerative colitis (UC), and controls without colectomy were sampled from within the same cohort, matching on gender, calendar year, and year of birth. We used Cox regression to examine the effect of colectomy on the hazard rates of gallstone disease and cholecystectomy, adjusting for alcoholism, stroke, chronic obstructive pulmonary disease, cancer, cardiac disease, diabetes mellitus, hypothyroidism, hyperlipidemia, cirrhosis, obesity, renal failure, and transient ischemic attacks. The effect of an IPAA was determined for patients who had colectomy by including the procedure as a time-dependent variable.RESULTS: We identified 4548 patients and matched these to 44 372 controls without colectomy. During a median follow-up of 11.9 years, 1963 patients were hospitalized for gallstone disease. Patients who had a colectomy were at an increased risk (adjusted hazard ratio (HR)=1.63 (1.39-1.91)), and sensitivity analyses of the risk of undergoing cholecystectomy revealed a similar association (adjusted HR=1.55 (1.22-1.98)). An IPAA did not affect the risk of developing gallstones among patients who had a colectomy (adjusted HR=1.03 (0.77-1.37)).CONCLUSION: The risk of gallstone disease increases following colectomy for UC.Am J Gastroenterol advance online publication, 24 January 2017; doi:10.1038/ajg.2016.564.

U2 - 10.1038/ajg.2016.564

DO - 10.1038/ajg.2016.564

M3 - Journal article

C2 - 28117363

VL - 112

SP - 473

EP - 478

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 3

ER -

ID: 49735309