Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Increased parathyroid expression of klotho in uremic rats

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Challenges and opportunities for nephrology in Western Europe

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Arterial oxygen content regulates plasma erythropoietin independent of arterial oxygen tension: a blinded crossover study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. U-shaped dietary sodium-associated incidence of chronic kidney disease cautions against salt overrestriction in hypertension

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Lowering LDL cholesterol reduces cardiovascular risk independently of presence of inflammation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Challenges and opportunities for nephrology in Western Europe

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Effect of inhibition of CBP-coactivated β-catenin-mediated Wnt signalling in uremic rats with vascular calcifications

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Klotho is a protein of significant importance for mineral homeostasis. It helps to increase parathyroid hormone (PTH) secretion and in the trafficking of Na+/K+-ATPase to the cell membrane; however, it is also a cofactor for fibroblast growth factor (FGF)-23 to interact with its receptor, FGFR1 IIIC, resulting in decreased PTH secretion. Studies on the regulation of parathyroid klotho expression in uremia have provided varying results. To help resolve this, we measured klotho expression in the parathyroid and its response to severe uremia, hyperphosphatemia, and calcitriol treatment in the 5/6 nephrectomy rat model of secondary hyperparathyroidism. Parathyroid klotho gene expression and protein were significantly increased in severely uremic hyperphosphatemic rats, but not affected by moderate uremia and normal serum phosphorus. Calcitriol suppressed klotho gene and protein expression in severe secondary hyperparathyroidism, despite a further increase in plasma phosphate. Both FGFR1 IIIC and Na+/K+-ATPase gene expression were significantly elevated in severe secondary hyperparathyroidism. Parathyroid gland klotho expression and the plasma calcium ion concentration were inversely correlated. Thus, our study suggests that klotho may act as a positive regulator of PTH expression and secretion in secondary hyperparathyroidism.
OriginalsprogEngelsk
TidsskriftKidney International
Vol/bind78
Udgave nummer11
Sider (fra-til)1119-27
Antal sider9
ISSN0085-2538
DOI
StatusUdgivet - 2010

ID: 31003773