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Increased frequency of rare missense PPP1R3B variants among Danish patients with type 2 diabetes

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  • Robina Khan Niazi
  • Jihua Sun
  • Christian Theil Have
  • Mette Hollensted
  • Allan Linneberg
  • Oluf Pedersen
  • Jens Steen Nielsen
  • Jørgen Rungby
  • Niels Grarup
  • Torben Hansen
  • Anette Prior Gjesing
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BACKGROUND: PPP1R3B has been suggested as a candidate gene for monogenic forms of diabetes as well as type 2 diabetes (T2D) due to its association with glycaemic trait and its biological role in glycogen synthesis.

OBJECTIVES: To study if rare missense variants in PPP1R3B increase the risk of maturity onset diabetes of the young (MODY), T2D or affect measures of glucose metabolism.

METHOD: Targeted resequencing of PPP1R3B was performed in 8,710 samples; MODY patients with unknown etiology (n = 54), newly diagnosed patients with T2D (n = 2,930) and population-based control individuals (n = 5,726, of whom n = 4,569 had normal glucose tolerance). All population-based sampled individuals were examined using an oral glucose tolerance test.

RESULTS: Among n = 396 carriers, we identified twenty-three PPP1R3B missense mutations, none of which segregated with MODY. The burden of likely deleterious PPP1R3B variants was significantly increased with a total of 17 carriers among patients with T2D (0.58% (95% CI: 0.36-0.93)) compared to 18 carriers among non-diabetic individuals (0.31% (95% CI: 0.20-0.49)), resulting in an increased risk of T2D (OR (95% CI) = 2.57 (1.14-5.79), p = 0.02 (age and sex adjusted)). Furthermore, carriers with diabetes had less abdominal fat and a higher serum concentration of LDL-cholesterol compared to patients with T2D without rare missense PPP1R3B variants. In addition, non-diabetic carriers had a higher birth weight compared to non-carriers.

CONCLUSION: Rare missense PPP1R3B variants may predispose to T2D.

OriginalsprogEngelsk
Artikelnummere0210114
TidsskriftPLoS One
Vol/bind14
Udgave nummer1
Sider (fra-til)e0210114
ISSN1932-6203
DOI
StatusUdgivet - 1 jan. 2019

ID: 56218281