Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Incidence of vulvar high-grade precancerous lesions and cancer in Denmark before and after introduction of HPV vaccination

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Non-epithelial ovarian cancer in Denmark - Incidence and survival over nearly 40 years

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Risk of endometrial cancer among women with benign ovarian tumors - A Danish nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Human papillomavirus genotype-specific risks for cervical intraepithelial lesions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Expanding our understanding of ovarian cancer risk: the role of incomplete pregnancies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Borderline ovarian tumors in Denmark 1997-2018: Time trends in incidence by histology, age and educational level

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Low-dose aspirin use and risk of head and neck cancer-A Danish nationwide case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Endometrial cancer risk after fertility treatment: a population-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Christina Louise Rasmussen
  • Louise T Thomsen
  • Gitte Lerche Aalborg
  • Susanne K Kjaer
Vis graf over relationer

OBJECTIVE: To assess the incidence of vulvar high-grade precancerous lesions and cancer in Denmark during 1997-2018.

METHODS: We identified incident vulvar cancer cases in the Danish Cancer Registry and incident cases of vulvar precancerous lesions in the Danish Pathology Register. We calculated age-standardized incidence rates of vulvar squamous cell carcinoma (VSCC), non-SCC and precancerous lesions, and age-specific incidence rates of VSCC and precancerous lesions. Incidence trends were evaluated using linear Poisson regression to estimate the average annual percentage change (AAPC). For vulvar precancerous lesions, trends were evaluated in the period before (1997-2007) and after (2008-2018) implementation of HPV vaccination.

RESULTS: In the 22-year study period, the age-standardized incidence rate of VSCC increased from 1.23 (1997-1998) to 1.98 per 100,000 (2017-2018), corresponding to an average yearly increase of 2.95% (95%CI: 2.15-3.75). The incidence of non-SCC increased only slightly. Overall, the incidence of vulvar precancerous lesions increased (AAPC = 2.38%; 95%CI: 1.75-3.02). After implementation of HPV vaccination, the incidence of vulvar precancerous lesions decreased significantly in women aged <20 (AAPC = -22.10% (95%CI: -35.27 to -6.26)) and 20-29 years (AAPC = -6.57, 95% CI: -10.63 to -2.33), whereas the incidence increased in the majority of age groups ≥50 years.

CONCLUSIONS: Overall, the incidence of VSCC and vulvar precancerous lesions increased during 1997-2018. However, after introduction of HPV vaccination, the incidence of vulvar precancerous lesions decreased among women aged <20 and 20-29 years, pointing towards a possible effect of HPV vaccination in this group. This development should be followed in the future.

OriginalsprogEngelsk
TidsskriftGynecologic Oncology
Vol/bind157
Udgave nummer3
Sider (fra-til)664-670
Antal sider7
ISSN0090-8258
DOI
StatusUdgivet - jun. 2020

Bibliografisk note

Copyright © 2020 Elsevier Inc. All rights reserved.

ID: 61557598