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Incidence of ischaemic stroke and mortality in patients with acute coronary syndrome and first-time detected atrial fibrillation: a nationwide study

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@article{6f00a07e5d97495ebfa3a139aef324ab,
title = "Incidence of ischaemic stroke and mortality in patients with acute coronary syndrome and first-time detected atrial fibrillation: a nationwide study",
abstract = "AIMS : The aim of this study was to examine contemporary data on the 1-year prognosis of patients surviving acute coronary syndrome (ACS) and concomitant first-time detected atrial fibrillation (AF).METHODS AND RESULTS: Using Danish nationwide registries, we identified all patients surviving a first-time admission with ACS from 2000 to 2018 and grouped them into (i) those without AF prior to or during ACS; (ii) those with a history of AF; and (iii) those with first-time detected AF during admission with ACS. With 1 year of follow-up, rates of ischaemic stroke, death, and bleeding were compared between study groups using multivariable adjusted Cox proportional hazards analysis. We included 161 266 ACS survivors: 135 878 (84.2%) without AF, 18 961 (11.8%) with history of AF, and 6427 (4.0%) with first-time detected AF at admission with ACS. Compared to those without AF, the adjusted 1-year rates of outcomes were as follows: ischaemic stroke [hazard ratio (HR) 1.38 (95% CI 1.22-1.56) for patients with history of AF and HR 1.67 (95% CI 1.38-2.01) for patients with first-time detected AF]; mortality [HR 1.25 (95% CI 1.21-1.31) for patients with history of AF and HR 1.52 (95% CI 1.43-1.62) for patients with first-time detected AF]; and bleeding [HR 1.22 (95% CI 1.14-1.30) for patients with history of AF and HR 1.28 (95% CI 1.15-1.43) for patients with first-time detected AF].CONCLUSION : In patients with ACS, first-time detected AF appeared to be at least as strongly associated with the 1-year rates of ischaemic stroke, mortality, and bleeding as compared with patients with a history of AF.",
keywords = "Acute Coronary Syndrome/epidemiology, Atrial Fibrillation/epidemiology, Brain Ischemia/epidemiology, Humans, Incidence, Ischemic Stroke, Registries, Risk Factors, Stroke/epidemiology, Myocardial infarction, Atrial fibrillation, Bleeding, Acute coronary syndrome, Unstable angina pectoris, Ischaemic stroke",
author = "Petersen, {Jeppe Kofoed} and {Haider Butt}, Jawad and Adelina Yafasova and Christian Torp-Pedersen and Rikke S{\o}rensen and Christina Kruuse and Vinding, {Naja Emborg} and Anna Gundlund and Lars K{\o}ber and {Loldrup Fosb{\o}l}, Emil and Lauge {\O}stergaard",
note = "Published on behalf of the European Society of Cardiology. All rights reserved. {\textcopyright} The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.",
year = "2021",
month = nov,
day = "21",
doi = "10.1093/eurheartj/ehab575",
language = "English",
volume = "42",
pages = "4553--4561",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "44",

}

RIS

TY - JOUR

T1 - Incidence of ischaemic stroke and mortality in patients with acute coronary syndrome and first-time detected atrial fibrillation

T2 - a nationwide study

AU - Petersen, Jeppe Kofoed

AU - Haider Butt, Jawad

AU - Yafasova, Adelina

AU - Torp-Pedersen, Christian

AU - Sørensen, Rikke

AU - Kruuse, Christina

AU - Vinding, Naja Emborg

AU - Gundlund, Anna

AU - Køber, Lars

AU - Loldrup Fosbøl, Emil

AU - Østergaard, Lauge

N1 - Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.

PY - 2021/11/21

Y1 - 2021/11/21

N2 - AIMS : The aim of this study was to examine contemporary data on the 1-year prognosis of patients surviving acute coronary syndrome (ACS) and concomitant first-time detected atrial fibrillation (AF).METHODS AND RESULTS: Using Danish nationwide registries, we identified all patients surviving a first-time admission with ACS from 2000 to 2018 and grouped them into (i) those without AF prior to or during ACS; (ii) those with a history of AF; and (iii) those with first-time detected AF during admission with ACS. With 1 year of follow-up, rates of ischaemic stroke, death, and bleeding were compared between study groups using multivariable adjusted Cox proportional hazards analysis. We included 161 266 ACS survivors: 135 878 (84.2%) without AF, 18 961 (11.8%) with history of AF, and 6427 (4.0%) with first-time detected AF at admission with ACS. Compared to those without AF, the adjusted 1-year rates of outcomes were as follows: ischaemic stroke [hazard ratio (HR) 1.38 (95% CI 1.22-1.56) for patients with history of AF and HR 1.67 (95% CI 1.38-2.01) for patients with first-time detected AF]; mortality [HR 1.25 (95% CI 1.21-1.31) for patients with history of AF and HR 1.52 (95% CI 1.43-1.62) for patients with first-time detected AF]; and bleeding [HR 1.22 (95% CI 1.14-1.30) for patients with history of AF and HR 1.28 (95% CI 1.15-1.43) for patients with first-time detected AF].CONCLUSION : In patients with ACS, first-time detected AF appeared to be at least as strongly associated with the 1-year rates of ischaemic stroke, mortality, and bleeding as compared with patients with a history of AF.

AB - AIMS : The aim of this study was to examine contemporary data on the 1-year prognosis of patients surviving acute coronary syndrome (ACS) and concomitant first-time detected atrial fibrillation (AF).METHODS AND RESULTS: Using Danish nationwide registries, we identified all patients surviving a first-time admission with ACS from 2000 to 2018 and grouped them into (i) those without AF prior to or during ACS; (ii) those with a history of AF; and (iii) those with first-time detected AF during admission with ACS. With 1 year of follow-up, rates of ischaemic stroke, death, and bleeding were compared between study groups using multivariable adjusted Cox proportional hazards analysis. We included 161 266 ACS survivors: 135 878 (84.2%) without AF, 18 961 (11.8%) with history of AF, and 6427 (4.0%) with first-time detected AF at admission with ACS. Compared to those without AF, the adjusted 1-year rates of outcomes were as follows: ischaemic stroke [hazard ratio (HR) 1.38 (95% CI 1.22-1.56) for patients with history of AF and HR 1.67 (95% CI 1.38-2.01) for patients with first-time detected AF]; mortality [HR 1.25 (95% CI 1.21-1.31) for patients with history of AF and HR 1.52 (95% CI 1.43-1.62) for patients with first-time detected AF]; and bleeding [HR 1.22 (95% CI 1.14-1.30) for patients with history of AF and HR 1.28 (95% CI 1.15-1.43) for patients with first-time detected AF].CONCLUSION : In patients with ACS, first-time detected AF appeared to be at least as strongly associated with the 1-year rates of ischaemic stroke, mortality, and bleeding as compared with patients with a history of AF.

KW - Acute Coronary Syndrome/epidemiology

KW - Atrial Fibrillation/epidemiology

KW - Brain Ischemia/epidemiology

KW - Humans

KW - Incidence

KW - Ischemic Stroke

KW - Registries

KW - Risk Factors

KW - Stroke/epidemiology

KW - Myocardial infarction

KW - Atrial fibrillation

KW - Bleeding

KW - Acute coronary syndrome

KW - Unstable angina pectoris

KW - Ischaemic stroke

UR - http://www.scopus.com/inward/record.url?scp=85119984599&partnerID=8YFLogxK

U2 - 10.1093/eurheartj/ehab575

DO - 10.1093/eurheartj/ehab575

M3 - Journal article

C2 - 34477838

VL - 42

SP - 4553

EP - 4561

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 44

M1 - ehab575

ER -

ID: 67500085