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Udgivet

Incidence of atrial fibrillation in conjunction with breast cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Maria D'Souza
  • Lærke Smedegaard
  • Christian Madelaire
  • Dorte Nielsen
  • Christian Torp-Pedersen
  • Gunnar Gislason
  • Morten Schou
  • Emil Fosbøl
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Background: Patients with breast cancer may have an increased incidence of atrial fibrillation (AF) because of the systemic inflammation induced by the cancer and side effects of treatments. Objective: The purpose of this study was to estimate the long-term incidence of AF in patients with breast cancer compared with the background population. Methods: We identified patients diagnosed with breast cancer from 1998 to 2015 by using nationwide registries. Female patients with breast cancer were matched (1:3) by age and sex with the background population. The long-term incidence of AF was estimated by cumulative incidence curves and multivariable Cox regression models. Results: We matched 74,155 patients with breast cancer with 222,465 patients from the background population. Breast cancer was associated with incident AF and the association differed between age groups (interaction analysis, P <.0001) and follow-up time periods. In patients younger than 60 years breast cancer was associated with increased incidence of AF during the first 6 months (hazard ratio [HR] 2.10; 95% confidence interval [CI] 1.25–3.44) and from 6 months to 3 years (HR 1.80; 95% CI 1.38–2.35). In patients older than 60 years, breast cancer was not associated with increased incidence of AF during the first 6 months (HR 1.13; 95% CI 0.95–1.34) and was associated with increased incidence of AF from 6 months to 3 years (HR 1.14; 95% CI 1.05–1.25). Conclusion: The long-term incidence of AF was increased in patients with breast cancer and short-term incidence was increased in patients younger than 60 years and similar in patients older than 60 years compared with the background population.

OriginalsprogEngelsk
TidsskriftHeart Rhythm
Vol/bind16
Udgave nummer3
Sider (fra-til)343-348
Antal sider6
ISSN1547-5271
DOI
StatusUdgivet - 1 mar. 2019

Bibliografisk note

Copyright © 2018 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

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