Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Incidence of acute coronary syndrome during national lock-down: insights from nationwide data during the coronavirus disease 2019 (COVID-19) pandemic

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Østergaard, Lauge ; Butt, Jawad Haider ; Kragholm, Kristian ; Schou, Morten ; Phelps, Matthew ; Sørensen, Rikke ; Lamberts, Morten ; Gislason, Gunnar ; Torp-Pedersen, Christian ; Køber, Lars ; Fosbøl, Emil L. / Incidence of acute coronary syndrome during national lock-down : insights from nationwide data during the coronavirus disease 2019 (COVID-19) pandemic. I: American Heart Journal. 2021 ; Bind 232. s. 146-153.

Bibtex

@article{bde003edfef04ea48e62d1e2c0189521,
title = "Incidence of acute coronary syndrome during national lock-down: insights from nationwide data during the coronavirus disease 2019 (COVID-19) pandemic",
abstract = "BACKGROUND: Urgent recognition and treatment are needed in patients with acute coronary syndrome (ACS), however this may be difficult during the Coronavirus disease 2019 (COVID-19) pandemic with a national lock-down. We aimed to examine the incidence of ACS after national lock-down.METHODS: The Danish government announced national lock-down on March 11, 2020 and first phase of reopening was announced on April 6. Using Danish nationwide registries, we identified first-time ACS admissions in (1) January 1 to May 7, 2017-2019, and (2) January 1, 2020 to May 6, 2020. Incidence rates of ACS admissions per week for the 2017 to 2019 period and the 2020 period were computed and incidence rate ratios (IRR) were computed using Poisson regression analysis.RESULTS: The number of ACS admissions were 8,204 (34.6% female, median age 68.3 years) and 2,577 (34.0% female, median age 68.5 years) for the 2017 to 2019- and 2020 period, respectively. No significant differences in IRRs were identified for weeks 1 to 9 (January 1 to March 4) for 2020 compared with week 1 to 9 for 2017 to 2019. In 2020, significant lower IRRs were identified for week 10 (March 5 to 11) IRR = 0.71 (95% confidence intervals [CI]: 0.58 to 0.87), week 11 (12 to 18 March) IRR = 0.68 (0.56 to 0.84), and week 14 (April 2 to April 8) IRR = 0.79 (0.65 to 0.97). No significant differences in IRRs were identified for week 15 to 18 (April 9 to May 6). In subgroup analysis, we identified that the main result was driven by male patients, and patients ≥60 years.CONCLUSIONS: During the COVID-19 pandemic with an established national lock-down we identified a significant decline around 30% in the incidence of ACS admissions. Along with the reopening of society, ACS admissions were stabilized at levels equal to previous years.",
keywords = "Acute Coronary Syndrome/epidemiology, Aged, COVID-19/epidemiology, Comorbidity, Confidence Intervals, Denmark/epidemiology, Female, Hospitalization/statistics & numerical data, Humans, Incidence, Male, Middle Aged, Pandemics/statistics & numerical data, Poisson Distribution, Quarantine/statistics & numerical data, Registries/statistics & numerical data, SARS-CoV-2, Sex Distribution, Time Factors",
author = "Lauge {\O}stergaard and Butt, {Jawad Haider} and Kristian Kragholm and Morten Schou and Matthew Phelps and Rikke S{\o}rensen and Morten Lamberts and Gunnar Gislason and Christian Torp-Pedersen and Lars K{\o}ber and Fosb{\o}l, {Emil L}",
note = "Copyright {\textcopyright} 2020 Elsevier Inc. All rights reserved.",
year = "2021",
month = feb,
doi = "10.1016/j.ahj.2020.11.004",
language = "English",
volume = "232",
pages = "146--153",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby, Inc",

}

RIS

TY - JOUR

T1 - Incidence of acute coronary syndrome during national lock-down

T2 - insights from nationwide data during the coronavirus disease 2019 (COVID-19) pandemic

AU - Østergaard, Lauge

AU - Butt, Jawad Haider

AU - Kragholm, Kristian

AU - Schou, Morten

AU - Phelps, Matthew

AU - Sørensen, Rikke

AU - Lamberts, Morten

AU - Gislason, Gunnar

AU - Torp-Pedersen, Christian

AU - Køber, Lars

AU - Fosbøl, Emil L

N1 - Copyright © 2020 Elsevier Inc. All rights reserved.

PY - 2021/2

Y1 - 2021/2

N2 - BACKGROUND: Urgent recognition and treatment are needed in patients with acute coronary syndrome (ACS), however this may be difficult during the Coronavirus disease 2019 (COVID-19) pandemic with a national lock-down. We aimed to examine the incidence of ACS after national lock-down.METHODS: The Danish government announced national lock-down on March 11, 2020 and first phase of reopening was announced on April 6. Using Danish nationwide registries, we identified first-time ACS admissions in (1) January 1 to May 7, 2017-2019, and (2) January 1, 2020 to May 6, 2020. Incidence rates of ACS admissions per week for the 2017 to 2019 period and the 2020 period were computed and incidence rate ratios (IRR) were computed using Poisson regression analysis.RESULTS: The number of ACS admissions were 8,204 (34.6% female, median age 68.3 years) and 2,577 (34.0% female, median age 68.5 years) for the 2017 to 2019- and 2020 period, respectively. No significant differences in IRRs were identified for weeks 1 to 9 (January 1 to March 4) for 2020 compared with week 1 to 9 for 2017 to 2019. In 2020, significant lower IRRs were identified for week 10 (March 5 to 11) IRR = 0.71 (95% confidence intervals [CI]: 0.58 to 0.87), week 11 (12 to 18 March) IRR = 0.68 (0.56 to 0.84), and week 14 (April 2 to April 8) IRR = 0.79 (0.65 to 0.97). No significant differences in IRRs were identified for week 15 to 18 (April 9 to May 6). In subgroup analysis, we identified that the main result was driven by male patients, and patients ≥60 years.CONCLUSIONS: During the COVID-19 pandemic with an established national lock-down we identified a significant decline around 30% in the incidence of ACS admissions. Along with the reopening of society, ACS admissions were stabilized at levels equal to previous years.

AB - BACKGROUND: Urgent recognition and treatment are needed in patients with acute coronary syndrome (ACS), however this may be difficult during the Coronavirus disease 2019 (COVID-19) pandemic with a national lock-down. We aimed to examine the incidence of ACS after national lock-down.METHODS: The Danish government announced national lock-down on March 11, 2020 and first phase of reopening was announced on April 6. Using Danish nationwide registries, we identified first-time ACS admissions in (1) January 1 to May 7, 2017-2019, and (2) January 1, 2020 to May 6, 2020. Incidence rates of ACS admissions per week for the 2017 to 2019 period and the 2020 period were computed and incidence rate ratios (IRR) were computed using Poisson regression analysis.RESULTS: The number of ACS admissions were 8,204 (34.6% female, median age 68.3 years) and 2,577 (34.0% female, median age 68.5 years) for the 2017 to 2019- and 2020 period, respectively. No significant differences in IRRs were identified for weeks 1 to 9 (January 1 to March 4) for 2020 compared with week 1 to 9 for 2017 to 2019. In 2020, significant lower IRRs were identified for week 10 (March 5 to 11) IRR = 0.71 (95% confidence intervals [CI]: 0.58 to 0.87), week 11 (12 to 18 March) IRR = 0.68 (0.56 to 0.84), and week 14 (April 2 to April 8) IRR = 0.79 (0.65 to 0.97). No significant differences in IRRs were identified for week 15 to 18 (April 9 to May 6). In subgroup analysis, we identified that the main result was driven by male patients, and patients ≥60 years.CONCLUSIONS: During the COVID-19 pandemic with an established national lock-down we identified a significant decline around 30% in the incidence of ACS admissions. Along with the reopening of society, ACS admissions were stabilized at levels equal to previous years.

KW - Acute Coronary Syndrome/epidemiology

KW - Aged

KW - COVID-19/epidemiology

KW - Comorbidity

KW - Confidence Intervals

KW - Denmark/epidemiology

KW - Female

KW - Hospitalization/statistics & numerical data

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Pandemics/statistics & numerical data

KW - Poisson Distribution

KW - Quarantine/statistics & numerical data

KW - Registries/statistics & numerical data

KW - SARS-CoV-2

KW - Sex Distribution

KW - Time Factors

U2 - 10.1016/j.ahj.2020.11.004

DO - 10.1016/j.ahj.2020.11.004

M3 - Journal article

C2 - 33160947

VL - 232

SP - 146

EP - 153

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

ER -

ID: 61351574