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Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901-2014: a nationwide study

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Mathiesen, JS, Kroustrup, JP, Vestergaard, P, Stochholm, K, Poulsen, PL, Rasmussen, ÅK, Feldt-Rasmussen, U, Schytte, S, Pedersen, HB, Hahn, CH, Bentzen, J, Möller, S, Gaustadnes, M, Rossing, M, Nielsen, FC, Brixen, K, Frederiksen, AL & Godballe, C 2018, 'Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901-2014: a nationwide study' Clinical Epidemiology, bind 10, s. 1479-1487. https://doi.org/10.2147/CLEP.S174606

APA

Mathiesen, J. S., Kroustrup, J. P., Vestergaard, P., Stochholm, K., Poulsen, P. L., Rasmussen, Å. K., ... Godballe, C. (2018). Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901-2014: a nationwide study. Clinical Epidemiology, 10, 1479-1487. https://doi.org/10.2147/CLEP.S174606

CBE

Mathiesen JS, Kroustrup JP, Vestergaard P, Stochholm K, Poulsen PL, Rasmussen ÅK, Feldt-Rasmussen U, Schytte S, Pedersen HB, Hahn CH, Bentzen J, Möller S, Gaustadnes M, Rossing M, Nielsen FC, Brixen K, Frederiksen AL, Godballe C. 2018. Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901-2014: a nationwide study. Clinical Epidemiology. 10:1479-1487. https://doi.org/10.2147/CLEP.S174606

MLA

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Author

Mathiesen, Jes Sloth ; Kroustrup, Jens Peter ; Vestergaard, Peter ; Stochholm, Kirstine ; Poulsen, Per Løgstrup ; Rasmussen, Åse Krogh ; Feldt-Rasmussen, Ulla ; Schytte, Sten ; Pedersen, Henrik Baymler ; Hahn, Christoffer Holst ; Bentzen, Jens ; Möller, Sören ; Gaustadnes, Mette ; Rossing, Maria ; Nielsen, Finn Cilius ; Brixen, Kim ; Frederiksen, Anja Lisbeth ; Godballe, Christian. / Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901-2014 : a nationwide study. I: Clinical Epidemiology. 2018 ; Bind 10. s. 1479-1487.

Bibtex

@article{31c23e89ea0d42a6a077f1036cfed762,
title = "Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901-2014: a nationwide study",
abstract = "Background: The incidence and prevalence of multiple endocrine neoplasia 2A (MEN2A) have only been reported once in a nationwide setting. However, it is unclear whether the figures are representative of other populations, as the major component of the syndrome, hereditary medullary thyroid carcinoma (MTC), has been reported as rare in the same country. We conducted a nationwide retrospective cohort study of MEN2A in Denmark from 1901 to 2014, aiming to describe the incidence and prevalence.Methods: This study included 250 unique MEN2A patients born or resident in Denmark before December 31, 2014. Patients were identified through the Danish REarranged during Transfection (RET) cohort, linkage of MEN2A pedigrees, the Danish MTC cohort, a nationwide collaboration of MEN2 centers, cross-checking of other relevant cohorts, and a systematic literature search.Results: The incidence from 1971 to 2000 was 28 (95{\%} CI: 21-37) per million live births per year. Incidence for the specific mutations or for the overall MEN2A group did not change significantly from 1901 to 2014 (P>0.05). Point prevalence at January 1, 2015, was 24 per million (95{\%} CI: 20-28).Conclusion: The incidence and prevalence of MEN2A in Denmark seem higher than those reported in other countries. This is likely explained by the Danish C611Y founder effect. Also, our data indicate no significant change in MEN2A incidence during the last century.",
author = "Mathiesen, {Jes Sloth} and Kroustrup, {Jens Peter} and Peter Vestergaard and Kirstine Stochholm and Poulsen, {Per L{\o}gstrup} and Rasmussen, {{\AA}se Krogh} and Ulla Feldt-Rasmussen and Sten Schytte and Pedersen, {Henrik Baymler} and Hahn, {Christoffer Holst} and Jens Bentzen and S{\"o}ren M{\"o}ller and Mette Gaustadnes and Maria Rossing and Nielsen, {Finn Cilius} and Kim Brixen and Frederiksen, {Anja Lisbeth} and Christian Godballe",
year = "2018",
month = "10",
doi = "10.2147/CLEP.S174606",
language = "English",
volume = "10",
pages = "1479--1487",
journal = "Clinical Epidemiology",
issn = "1179-1349",
publisher = "Dove Medical Press Ltd",

}

RIS

TY - JOUR

T1 - Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901-2014

T2 - a nationwide study

AU - Mathiesen, Jes Sloth

AU - Kroustrup, Jens Peter

AU - Vestergaard, Peter

AU - Stochholm, Kirstine

AU - Poulsen, Per Løgstrup

AU - Rasmussen, Åse Krogh

AU - Feldt-Rasmussen, Ulla

AU - Schytte, Sten

AU - Pedersen, Henrik Baymler

AU - Hahn, Christoffer Holst

AU - Bentzen, Jens

AU - Möller, Sören

AU - Gaustadnes, Mette

AU - Rossing, Maria

AU - Nielsen, Finn Cilius

AU - Brixen, Kim

AU - Frederiksen, Anja Lisbeth

AU - Godballe, Christian

PY - 2018/10

Y1 - 2018/10

N2 - Background: The incidence and prevalence of multiple endocrine neoplasia 2A (MEN2A) have only been reported once in a nationwide setting. However, it is unclear whether the figures are representative of other populations, as the major component of the syndrome, hereditary medullary thyroid carcinoma (MTC), has been reported as rare in the same country. We conducted a nationwide retrospective cohort study of MEN2A in Denmark from 1901 to 2014, aiming to describe the incidence and prevalence.Methods: This study included 250 unique MEN2A patients born or resident in Denmark before December 31, 2014. Patients were identified through the Danish REarranged during Transfection (RET) cohort, linkage of MEN2A pedigrees, the Danish MTC cohort, a nationwide collaboration of MEN2 centers, cross-checking of other relevant cohorts, and a systematic literature search.Results: The incidence from 1971 to 2000 was 28 (95% CI: 21-37) per million live births per year. Incidence for the specific mutations or for the overall MEN2A group did not change significantly from 1901 to 2014 (P>0.05). Point prevalence at January 1, 2015, was 24 per million (95% CI: 20-28).Conclusion: The incidence and prevalence of MEN2A in Denmark seem higher than those reported in other countries. This is likely explained by the Danish C611Y founder effect. Also, our data indicate no significant change in MEN2A incidence during the last century.

AB - Background: The incidence and prevalence of multiple endocrine neoplasia 2A (MEN2A) have only been reported once in a nationwide setting. However, it is unclear whether the figures are representative of other populations, as the major component of the syndrome, hereditary medullary thyroid carcinoma (MTC), has been reported as rare in the same country. We conducted a nationwide retrospective cohort study of MEN2A in Denmark from 1901 to 2014, aiming to describe the incidence and prevalence.Methods: This study included 250 unique MEN2A patients born or resident in Denmark before December 31, 2014. Patients were identified through the Danish REarranged during Transfection (RET) cohort, linkage of MEN2A pedigrees, the Danish MTC cohort, a nationwide collaboration of MEN2 centers, cross-checking of other relevant cohorts, and a systematic literature search.Results: The incidence from 1971 to 2000 was 28 (95% CI: 21-37) per million live births per year. Incidence for the specific mutations or for the overall MEN2A group did not change significantly from 1901 to 2014 (P>0.05). Point prevalence at January 1, 2015, was 24 per million (95% CI: 20-28).Conclusion: The incidence and prevalence of MEN2A in Denmark seem higher than those reported in other countries. This is likely explained by the Danish C611Y founder effect. Also, our data indicate no significant change in MEN2A incidence during the last century.

U2 - 10.2147/CLEP.S174606

DO - 10.2147/CLEP.S174606

M3 - Journal article

VL - 10

SP - 1479

EP - 1487

JO - Clinical Epidemiology

JF - Clinical Epidemiology

SN - 1179-1349

ER -

ID: 56132907