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Impaired serum inhibin-B and number of germ cells in boys with cryptorchidism following heavily gestational maternal smoking

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@article{180f10fa5c6643018c1fcb1b492b2546,
title = "Impaired serum inhibin-B and number of germ cells in boys with cryptorchidism following heavily gestational maternal smoking",
abstract = "PURPOSE: A meta-analysis including 11,900 cases showed that maternal gestational smoking was associated with increased risk of cryptorchidism. The aim of study was to investigate whether a hormone profile of cryptorchid boys and a supplementing histopathological evaluation of testicular biopsies could add detailed knowledge to the impact of maternal gestational smoking on pathogenesis of cryptorchidism.METHODS: 601 cryptorchid boys aged 4 months to 14 years old were included. Because normal hormones have a pronounced age dependency, we compared results from boys whose mothers had smoked heavily (>10 cigarettes/day) during pregnancy with age matched cryptorchid controls of nonsmoking mothers (1:6). We studied: birthweight, germ-cell number/tubular cross section, frequency of germ cells positive for placental-like alkaline phosphatase (PLAP), gonadotropins and inhibin-B.RESULTS: 501 boys were sons of nonsmokers, 72 boys of intermittent smokers and 28 boys of heavy smokers. 39{\%}, 44{\%} and 61{\%} respectively had bilateral cryptorchidism. Compared to age-matched cryptorchid controls of nonsmoking mothers, sons of heavy smokers had lower birthweight (p = 0.006), germ-cell number/tubular cross section (p = 0.009), frequency of germ cells positive for PLAP (p = 0.037) and inhibin-B (p = 0.042).CONCLUSIONS: All findings could be associated with placental dysfunction with altered human chorionic gonadotropin production well described in women smoking during pregnancy.TYPE OF STUDY: Prognosis study (prospective cohort study with >80{\%} follow-up).LEVEL OF EVIDENCE: Level 1.",
keywords = "Cryptorchidism, Fertility, Germ cells, Gestational maternal smoking, Gonodotrophins, Inhibin-B",
author = "Simone Hildorf and Erik Clasen-Linde and Lihua Dong and Dina Cortes and Jorgen Thorup",
note = "Copyright {\circledC} 2018 Elsevier Inc. All rights reserved.",
year = "2019",
month = "4",
day = "1",
doi = "10.1016/j.jpedsurg.2018.03.026",
language = "English",
volume = "54",
pages = "809--814",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B./Saunders Co",
number = "4",

}

RIS

TY - JOUR

T1 - Impaired serum inhibin-B and number of germ cells in boys with cryptorchidism following heavily gestational maternal smoking

AU - Hildorf, Simone

AU - Clasen-Linde, Erik

AU - Dong, Lihua

AU - Cortes, Dina

AU - Thorup, Jorgen

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - PURPOSE: A meta-analysis including 11,900 cases showed that maternal gestational smoking was associated with increased risk of cryptorchidism. The aim of study was to investigate whether a hormone profile of cryptorchid boys and a supplementing histopathological evaluation of testicular biopsies could add detailed knowledge to the impact of maternal gestational smoking on pathogenesis of cryptorchidism.METHODS: 601 cryptorchid boys aged 4 months to 14 years old were included. Because normal hormones have a pronounced age dependency, we compared results from boys whose mothers had smoked heavily (>10 cigarettes/day) during pregnancy with age matched cryptorchid controls of nonsmoking mothers (1:6). We studied: birthweight, germ-cell number/tubular cross section, frequency of germ cells positive for placental-like alkaline phosphatase (PLAP), gonadotropins and inhibin-B.RESULTS: 501 boys were sons of nonsmokers, 72 boys of intermittent smokers and 28 boys of heavy smokers. 39%, 44% and 61% respectively had bilateral cryptorchidism. Compared to age-matched cryptorchid controls of nonsmoking mothers, sons of heavy smokers had lower birthweight (p = 0.006), germ-cell number/tubular cross section (p = 0.009), frequency of germ cells positive for PLAP (p = 0.037) and inhibin-B (p = 0.042).CONCLUSIONS: All findings could be associated with placental dysfunction with altered human chorionic gonadotropin production well described in women smoking during pregnancy.TYPE OF STUDY: Prognosis study (prospective cohort study with >80% follow-up).LEVEL OF EVIDENCE: Level 1.

AB - PURPOSE: A meta-analysis including 11,900 cases showed that maternal gestational smoking was associated with increased risk of cryptorchidism. The aim of study was to investigate whether a hormone profile of cryptorchid boys and a supplementing histopathological evaluation of testicular biopsies could add detailed knowledge to the impact of maternal gestational smoking on pathogenesis of cryptorchidism.METHODS: 601 cryptorchid boys aged 4 months to 14 years old were included. Because normal hormones have a pronounced age dependency, we compared results from boys whose mothers had smoked heavily (>10 cigarettes/day) during pregnancy with age matched cryptorchid controls of nonsmoking mothers (1:6). We studied: birthweight, germ-cell number/tubular cross section, frequency of germ cells positive for placental-like alkaline phosphatase (PLAP), gonadotropins and inhibin-B.RESULTS: 501 boys were sons of nonsmokers, 72 boys of intermittent smokers and 28 boys of heavy smokers. 39%, 44% and 61% respectively had bilateral cryptorchidism. Compared to age-matched cryptorchid controls of nonsmoking mothers, sons of heavy smokers had lower birthweight (p = 0.006), germ-cell number/tubular cross section (p = 0.009), frequency of germ cells positive for PLAP (p = 0.037) and inhibin-B (p = 0.042).CONCLUSIONS: All findings could be associated with placental dysfunction with altered human chorionic gonadotropin production well described in women smoking during pregnancy.TYPE OF STUDY: Prognosis study (prospective cohort study with >80% follow-up).LEVEL OF EVIDENCE: Level 1.

KW - Cryptorchidism

KW - Fertility

KW - Germ cells

KW - Gestational maternal smoking

KW - Gonodotrophins

KW - Inhibin-B

UR - http://www.scopus.com/inward/record.url?scp=85046115906&partnerID=8YFLogxK

U2 - 10.1016/j.jpedsurg.2018.03.026

DO - 10.1016/j.jpedsurg.2018.03.026

M3 - Journal article

VL - 54

SP - 809

EP - 814

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

IS - 4

ER -

ID: 54183281