Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Impact of injecting drug use on response to highly active antiretroviral treatment in HIV-1-infected patients: a nationwide population-based cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Molecular imaging in Libman-Sacks endocarditis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Mycobacterium bovis meningitis in young Nigerian-born male

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Undetectable hepatitis C virus RNA during syphilis infection in two HIV/HCV-co-infected patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Pneumocystis jirovecii pneumonia in patients with end-stage renal disease: a comparison with the general population

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Antibacterial use in the Faroe Islands, Iceland, and Denmark 1999-2011

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. HIV infection is associated with type 2 diabetes mellitus

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. De novo electrocardiographic abnormalities in persons living with HIV

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. HIV infection is associated with thoracic and abdominal aortic aneurysms: a prospective matched cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Positive Predictive Value of ICD-10 Diagnosis Codes for COVID-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
The objective of this study was to determine the effect of highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV)-infected patients infected through injecting drug use (injecting drug users, IDUs) compared to patients infected via other routes (non-IDUs). We conducted a nationwide population-based cohort study of all HIV-infected patients who initiated HAART during the study period of 1 January 1995 to 31 December 2007. We compared changes in CD4(+) cell counts, percentage of full viral suppression (<500 copies/ml) and mortality from start of HAART, as well as differences in initial HAART regimen. Three thousand six hundred and fifteen patients were included in the study, representing 22,804 person-y of observation. A total of 346 (9.6%) were categorized as IDUs. Of IDUs, 55% gained full viral control within the first y after HAART compared to 76% of non-IDUs (p = 0.0002). Absolute CD4(+) cell count and survival were lower for IDUs compared to non-IDUs (adjusted mortality rate ratio 3.6 (95% CI 2.9-4.3)). IDUs were more likely to receive a first regimen based on protease inhibitors (PIs) compared to non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens for non-IDUs, and IDUs initiated HAART later than non-IDUs. In conclusion, more than half of the HIV-infected patients in Denmark infected through injecting drug use gained full viral suppression after initiating HAART. Absolute CD4(+) cell count was lower and mortality higher among IDUs than non-IDUs.
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Infectious Diseases
Vol/bind42
Udgave nummer11-12
Sider (fra-til)917-23
Antal sider7
ISSN0036-5548
DOI
StatusUdgivet - 1 dec. 2010

ID: 32217713