Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Impact of chronic diseases on effect of breast cancer screening

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Beau, A-B, Napolitano, GM, Ewertz, M, Vejborg, I, Schwartz, W, Andersen, PK & Lynge, E 2020, 'Impact of chronic diseases on effect of breast cancer screening', Cancer Medicine, bind 9, nr. 11, s. 3995-4003. https://doi.org/10.1002/cam4.3036

APA

Beau, A-B., Napolitano, G. M., Ewertz, M., Vejborg, I., Schwartz, W., Andersen, P. K., & Lynge, E. (2020). Impact of chronic diseases on effect of breast cancer screening. Cancer Medicine, 9(11), 3995-4003. https://doi.org/10.1002/cam4.3036

CBE

Beau A-B, Napolitano GM, Ewertz M, Vejborg I, Schwartz W, Andersen PK, Lynge E. 2020. Impact of chronic diseases on effect of breast cancer screening. Cancer Medicine. 9(11):3995-4003. https://doi.org/10.1002/cam4.3036

MLA

Vancouver

Beau A-B, Napolitano GM, Ewertz M, Vejborg I, Schwartz W, Andersen PK o.a. Impact of chronic diseases on effect of breast cancer screening. Cancer Medicine. 2020 jun;9(11):3995-4003. https://doi.org/10.1002/cam4.3036

Author

Beau, Anna-Belle ; Napolitano, George M ; Ewertz, Marianne ; Vejborg, Ilse ; Schwartz, Walter ; Andersen, Per K ; Lynge, Elsebeth. / Impact of chronic diseases on effect of breast cancer screening. I: Cancer Medicine. 2020 ; Bind 9, Nr. 11. s. 3995-4003.

Bibtex

@article{731fd68df267411aba01eed2778665d9,
title = "Impact of chronic diseases on effect of breast cancer screening",
abstract = "BACKGROUND: Although breast cancer screening reduces breast cancer mortality at the population level, subgroups of women may benefit differently. We investigated the impact of health status on the effect of breast cancer screening.METHODS: The study included 181 299 women invited in two population-based screening programs in Denmark and 1 526 446 control subjects, followed from April 1981 to December 2014. Poisson regressions were used to compare the observed breast cancer mortality rate in women invited to screening with the expected rate in the absence of screening among women with and without chronic diseases. Chronic diseases were defined as any diagnosis in the Charlson Comorbidity Index during 4 years before the first invitation to screening.RESULTS: Almost 10% of women had chronic diseases before first invitation to screening. Whereas we observed a reduction in breast cancer mortality following invitation to screening of 28% (95% CI, 20% to 35%) among women without chronic diseases, only a 7% (95% CI, -39% to 37%) reduction was seen for women with chronic diseases (P-value for interaction = .22). For participants, the reduction, corrected for selection bias, was 35% (95% CI 16% to 49%) for women without, and 4% (95% CI -146% to 62%) for women with chronic diseases (P-value for interaction = .43).CONCLUSION: Our data indicate a marginal effect of mammography screening on breast cancer mortality in women with chronic diseases. If our results are confirmed in other populations, the presence of chronic diseases will be an important factor to take into consideration in personalized screening.",
author = "Anna-Belle Beau and Napolitano, {George M} and Marianne Ewertz and Ilse Vejborg and Walter Schwartz and Andersen, {Per K} and Elsebeth Lynge",
note = "{\textcopyright} 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.",
year = "2020",
month = jun,
doi = "10.1002/cam4.3036",
language = "English",
volume = "9",
pages = "3995--4003",
journal = "Cancer Medicine",
issn = "2045-7634",
publisher = "John Wiley and Sons Ltd",
number = "11",

}

RIS

TY - JOUR

T1 - Impact of chronic diseases on effect of breast cancer screening

AU - Beau, Anna-Belle

AU - Napolitano, George M

AU - Ewertz, Marianne

AU - Vejborg, Ilse

AU - Schwartz, Walter

AU - Andersen, Per K

AU - Lynge, Elsebeth

N1 - © 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

PY - 2020/6

Y1 - 2020/6

N2 - BACKGROUND: Although breast cancer screening reduces breast cancer mortality at the population level, subgroups of women may benefit differently. We investigated the impact of health status on the effect of breast cancer screening.METHODS: The study included 181 299 women invited in two population-based screening programs in Denmark and 1 526 446 control subjects, followed from April 1981 to December 2014. Poisson regressions were used to compare the observed breast cancer mortality rate in women invited to screening with the expected rate in the absence of screening among women with and without chronic diseases. Chronic diseases were defined as any diagnosis in the Charlson Comorbidity Index during 4 years before the first invitation to screening.RESULTS: Almost 10% of women had chronic diseases before first invitation to screening. Whereas we observed a reduction in breast cancer mortality following invitation to screening of 28% (95% CI, 20% to 35%) among women without chronic diseases, only a 7% (95% CI, -39% to 37%) reduction was seen for women with chronic diseases (P-value for interaction = .22). For participants, the reduction, corrected for selection bias, was 35% (95% CI 16% to 49%) for women without, and 4% (95% CI -146% to 62%) for women with chronic diseases (P-value for interaction = .43).CONCLUSION: Our data indicate a marginal effect of mammography screening on breast cancer mortality in women with chronic diseases. If our results are confirmed in other populations, the presence of chronic diseases will be an important factor to take into consideration in personalized screening.

AB - BACKGROUND: Although breast cancer screening reduces breast cancer mortality at the population level, subgroups of women may benefit differently. We investigated the impact of health status on the effect of breast cancer screening.METHODS: The study included 181 299 women invited in two population-based screening programs in Denmark and 1 526 446 control subjects, followed from April 1981 to December 2014. Poisson regressions were used to compare the observed breast cancer mortality rate in women invited to screening with the expected rate in the absence of screening among women with and without chronic diseases. Chronic diseases were defined as any diagnosis in the Charlson Comorbidity Index during 4 years before the first invitation to screening.RESULTS: Almost 10% of women had chronic diseases before first invitation to screening. Whereas we observed a reduction in breast cancer mortality following invitation to screening of 28% (95% CI, 20% to 35%) among women without chronic diseases, only a 7% (95% CI, -39% to 37%) reduction was seen for women with chronic diseases (P-value for interaction = .22). For participants, the reduction, corrected for selection bias, was 35% (95% CI 16% to 49%) for women without, and 4% (95% CI -146% to 62%) for women with chronic diseases (P-value for interaction = .43).CONCLUSION: Our data indicate a marginal effect of mammography screening on breast cancer mortality in women with chronic diseases. If our results are confirmed in other populations, the presence of chronic diseases will be an important factor to take into consideration in personalized screening.

U2 - 10.1002/cam4.3036

DO - 10.1002/cam4.3036

M3 - Journal article

C2 - 32253821

VL - 9

SP - 3995

EP - 4003

JO - Cancer Medicine

JF - Cancer Medicine

SN - 2045-7634

IS - 11

ER -

ID: 61865086