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Immunoparesis in newly diagnosed Multiple Myeloma patients: Effects on overall survival and progression free survival in the Danish population

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Harvard

Sørrig, R, Klausen, TW, Salomo, M, Vangsted, AJ, Frølund, UC, Andersen, KT, Klostergaard, A, Helleberg, C, Pedersen, RS, Pedersen, PT, Helm-Petersen, S, Teodorescu, EM, Preiss, B, Abildgaard, N, Gimsing, P & Danish Myeloma Study Group 2017, 'Immunoparesis in newly diagnosed Multiple Myeloma patients: Effects on overall survival and progression free survival in the Danish population' P L o S One, bind 12, nr. 12, s. e0188988. https://doi.org/10.1371/journal.pone.0188988

APA

CBE

Sørrig R, Klausen TW, Salomo M, Vangsted AJ, Frølund UC, Andersen KT, Klostergaard A, Helleberg C, Pedersen RS, Pedersen PT, Helm-Petersen S, Teodorescu EM, Preiss B, Abildgaard N, Gimsing P, Danish Myeloma Study Group. 2017. Immunoparesis in newly diagnosed Multiple Myeloma patients: Effects on overall survival and progression free survival in the Danish population. P L o S One. 12(12):e0188988. https://doi.org/10.1371/journal.pone.0188988

MLA

Vancouver

Author

Sørrig, Rasmus ; Klausen, Tobias W ; Salomo, Morten ; Vangsted, Annette J ; Frølund, Ulf Christian ; Andersen, Kristian T ; Klostergaard, Anja ; Helleberg, Carsten ; Pedersen, Robert S ; Pedersen, Per T ; Helm-Petersen, Sissel ; Teodorescu, Elena Manuela ; Preiss, Birgitte ; Abildgaard, Niels ; Gimsing, Peter ; Danish Myeloma Study Group. / Immunoparesis in newly diagnosed Multiple Myeloma patients : Effects on overall survival and progression free survival in the Danish population. I: P L o S One. 2017 ; Bind 12, Nr. 12. s. e0188988.

Bibtex

@article{1cdbaee1893d482e97f89cac1714cf6e,
title = "Immunoparesis in newly diagnosed Multiple Myeloma patients: Effects on overall survival and progression free survival in the Danish population",
abstract = "Immunoparesis (hypogammaglobulinemia) is associated to an unfavorable prognosis in newly diagnosed Multiple myeloma (MM) patients. However, this finding has not been validated in an unselected population-based cohort. We analyzed 2558 newly diagnosed MM patients in the Danish Multiple Myeloma Registry representing the entire MM population in Denmark from 2005-2013. Two-thousand two hundred and fifty three patients (90{\%}) presented with reduction below lower normal levels of at least one uninvolved immunoglobulin. Using multivariable Cox regression we found that high age, high ISS score, high LDH and IgA MM were associated to both shorter overall survival and progression free survival. Furthermore, bone marrow plasma cell {\%} was associated to short progression free survival. Immunoparesis had no independent significant effect on OS (HR 0.9 (95{\%}CI: 0.7;1.0; p = 0.12)). Likewise, the number of suppressed immunoglobulins or the relative degree of suppressed uninvolved immunoglobulins from lower normal level (quantitative immunoparesis) was not associated to OS in the multivariable analysis. However, quantitative immunoparesis with at least 25{\%} reduction (from lower normal level) of uninvolved immunoglobulins was associated to shorter PFS for the entire population. The impact of quantitative immunoparesis on PFS was present irrespective of calendar periods 2005-2008 and 2009-2013. Our population-based study does not confirm that immunoparesis at diagnosis is an independent prognostic factor regarding OS. However, quantitative immunoparesis is associated to a shorter PFS.",
keywords = "Adult, Agammaglobulinemia, Aged, Aged, 80 and over, Denmark, Female, Humans, Male, Middle Aged, Multiple Myeloma, Prognosis, Survival Analysis, Journal Article",
author = "Rasmus S{\o}rrig and Klausen, {Tobias W} and Morten Salomo and Vangsted, {Annette J} and Fr{\o}lund, {Ulf Christian} and Andersen, {Kristian T} and Anja Klostergaard and Carsten Helleberg and Pedersen, {Robert S} and Pedersen, {Per T} and Sissel Helm-Petersen and Teodorescu, {Elena Manuela} and Birgitte Preiss and Niels Abildgaard and Peter Gimsing and {Danish Myeloma Study Group}",
year = "2017",
doi = "10.1371/journal.pone.0188988",
language = "English",
volume = "12",
pages = "e0188988",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

RIS

TY - JOUR

T1 - Immunoparesis in newly diagnosed Multiple Myeloma patients

T2 - Effects on overall survival and progression free survival in the Danish population

AU - Sørrig, Rasmus

AU - Klausen, Tobias W

AU - Salomo, Morten

AU - Vangsted, Annette J

AU - Frølund, Ulf Christian

AU - Andersen, Kristian T

AU - Klostergaard, Anja

AU - Helleberg, Carsten

AU - Pedersen, Robert S

AU - Pedersen, Per T

AU - Helm-Petersen, Sissel

AU - Teodorescu, Elena Manuela

AU - Preiss, Birgitte

AU - Abildgaard, Niels

AU - Gimsing, Peter

AU - Danish Myeloma Study Group

PY - 2017

Y1 - 2017

N2 - Immunoparesis (hypogammaglobulinemia) is associated to an unfavorable prognosis in newly diagnosed Multiple myeloma (MM) patients. However, this finding has not been validated in an unselected population-based cohort. We analyzed 2558 newly diagnosed MM patients in the Danish Multiple Myeloma Registry representing the entire MM population in Denmark from 2005-2013. Two-thousand two hundred and fifty three patients (90%) presented with reduction below lower normal levels of at least one uninvolved immunoglobulin. Using multivariable Cox regression we found that high age, high ISS score, high LDH and IgA MM were associated to both shorter overall survival and progression free survival. Furthermore, bone marrow plasma cell % was associated to short progression free survival. Immunoparesis had no independent significant effect on OS (HR 0.9 (95%CI: 0.7;1.0; p = 0.12)). Likewise, the number of suppressed immunoglobulins or the relative degree of suppressed uninvolved immunoglobulins from lower normal level (quantitative immunoparesis) was not associated to OS in the multivariable analysis. However, quantitative immunoparesis with at least 25% reduction (from lower normal level) of uninvolved immunoglobulins was associated to shorter PFS for the entire population. The impact of quantitative immunoparesis on PFS was present irrespective of calendar periods 2005-2008 and 2009-2013. Our population-based study does not confirm that immunoparesis at diagnosis is an independent prognostic factor regarding OS. However, quantitative immunoparesis is associated to a shorter PFS.

AB - Immunoparesis (hypogammaglobulinemia) is associated to an unfavorable prognosis in newly diagnosed Multiple myeloma (MM) patients. However, this finding has not been validated in an unselected population-based cohort. We analyzed 2558 newly diagnosed MM patients in the Danish Multiple Myeloma Registry representing the entire MM population in Denmark from 2005-2013. Two-thousand two hundred and fifty three patients (90%) presented with reduction below lower normal levels of at least one uninvolved immunoglobulin. Using multivariable Cox regression we found that high age, high ISS score, high LDH and IgA MM were associated to both shorter overall survival and progression free survival. Furthermore, bone marrow plasma cell % was associated to short progression free survival. Immunoparesis had no independent significant effect on OS (HR 0.9 (95%CI: 0.7;1.0; p = 0.12)). Likewise, the number of suppressed immunoglobulins or the relative degree of suppressed uninvolved immunoglobulins from lower normal level (quantitative immunoparesis) was not associated to OS in the multivariable analysis. However, quantitative immunoparesis with at least 25% reduction (from lower normal level) of uninvolved immunoglobulins was associated to shorter PFS for the entire population. The impact of quantitative immunoparesis on PFS was present irrespective of calendar periods 2005-2008 and 2009-2013. Our population-based study does not confirm that immunoparesis at diagnosis is an independent prognostic factor regarding OS. However, quantitative immunoparesis is associated to a shorter PFS.

KW - Adult

KW - Agammaglobulinemia

KW - Aged

KW - Aged, 80 and over

KW - Denmark

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Multiple Myeloma

KW - Prognosis

KW - Survival Analysis

KW - Journal Article

U2 - 10.1371/journal.pone.0188988

DO - 10.1371/journal.pone.0188988

M3 - Journal article

VL - 12

SP - e0188988

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 12

ER -

ID: 52221765