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Rigshospitalet - en del af Københavns Universitetshospital
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Imaging of treatment response to the combination of carboplatin and paclitaxel in human ovarian cancer xenograft tumors in mice using FDG and FLT PET

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Vis graf over relationer
A combination of carboplatin and paclitaxel is often used as first line chemotherapy for treatment of ovarian cancer. Therefore the use of imaging biomarkers early after initiation of treatment to determine treatment sensitivity would be valuable in order to identify responders from non-responders. In this study we describe the non-invasive PET imaging of glucose uptake and cell proliferation using 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) and 3'-deoxy-3'-[(18)F]fluorothymidine (FLT) for early assessment of treatment response in a pre-clinical mouse model of human ovarian cancer treated with carboplatin and paclitaxel.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind8
Udgave nummer12
Sider (fra-til)e85126
ISSN1932-6203
DOI
StatusUdgivet - 2013

ID: 43158645