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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Imaging of Prostate Cancer Using Urokinase-Type Plasminogen Activator Receptor PET

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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Vis graf over relationer

Urokinase-type plasminogen activator receptor (uPAR) overexpression is an important biomarker for aggressiveness in cancer including prostate cancer (PC) and provides independent clinical information in addition to prostate-specific antigen and Gleason score. This article focuses on uPAR PET as a new diagnostic and prognostic imaging biomarker in PC. Many preclinical uPAR-targeted PET imaging studies using AE105 in cancer models have been undertaken with promising results. A major breakthrough was obtained with the recent human translation of uPAR PET in using 64Cu- and 68Ga-labelled versions of AE105, respectively. Clinical results from patients with PC included in these studies are encouraging and support continuation with large-scale clinical trials.

OriginalsprogEngelsk
TidsskriftPET Clinics
Vol/bind12
Udgave nummer2
Sider (fra-til)243-255
Antal sider13
ISSN1556-8598
DOI
StatusUdgivet - apr. 2017

ID: 55064550