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Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Catherine M Phelan
  • Karoline B Kuchenbaecker
  • Jonathan P Tyrer
  • Siddhartha P Kar
  • Kate Lawrenson
  • Stacey J Winham
  • Joe Dennis
  • Ailith Pirie
  • Marjorie J Riggan
  • Ganna Chornokur
  • Madalene A Earp
  • Paulo C Lyra
  • Janet M Lee
  • Simon Coetzee
  • Jonathan Beesley
  • Lesley McGuffog
  • Penny Soucy
  • Ed Dicks
  • Andrew Lee
  • Daniel Barrowdale
  • Julie Lecarpentier
  • Goska Leslie
  • Cora M Aalfs
  • Katja K H Aben
  • Marcia Adams
  • Julian Adlard
  • Irene L Andrulis
  • Hoda Anton-Culver
  • Natalia Antonenkova
  • Gerasimos Aravantinos
  • Norbert Arnold
  • Banu K Arun
  • Brita Arver
  • Jacopo Azzollini
  • Judith Balmaña
  • Susana N Banerjee
  • Laure Barjhoux
  • Rosa B Barkardottir
  • Yukie Bean
  • Matthias W Beckmann
  • Alicia Beeghly-Fadiel
  • Bent Ejlertsen
  • Anne-Marie Gerdes
  • Thomas V O Hansen
  • Claus K Høgdall
  • Estrid Høgdall
  • Allan Jensen
  • Susanne K Kjaer
  • Lene Lundvall
  • Lotte Nedergaard
  • AOCS study group
Vis graf over relationer

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.

OriginalsprogEngelsk
TidsskriftNature Genetics
Vol/bind49
Udgave nummer5
Sider (fra-til)680-691
Antal sider12
ISSN1061-4036
DOI
StatusUdgivet - maj 2017

ID: 50606620