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Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism

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Kristensen, DM, Desdoits-Lethimonier, C, Mackey, AL, Dalgaard, MD, De Masi, F, Munkbøl, CH, Styrishave, B, Antignac, J-P, Le Bizec, B, Platel, C, Hay-Schmidt, A, Jensen, TK, Lesné, L, Mazaud-Guittot, S, Kristiansen, K, Brunak, S, Kjaer, M, Juul, A & Jégou, B 2018, 'Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism' Proceedings of the National Academy of Sciences of the United States of America, bind 115, nr. 4, s. E715-E724. https://doi.org/10.1073/pnas.1715035115

APA

CBE

Kristensen DM, Desdoits-Lethimonier C, Mackey AL, Dalgaard MD, De Masi F, Munkbøl CH, Styrishave B, Antignac J-P, Le Bizec B, Platel C, Hay-Schmidt A, Jensen TK, Lesné L, Mazaud-Guittot S, Kristiansen K, Brunak S, Kjaer M, Juul A, Jégou B. 2018. Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism. Proceedings of the National Academy of Sciences of the United States of America. 115(4):E715-E724. https://doi.org/10.1073/pnas.1715035115

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Author

Kristensen, David Møbjerg ; Desdoits-Lethimonier, Christèle ; Mackey, Abigail L ; Dalgaard, Marlene Danner ; De Masi, Federico ; Munkbøl, Cecilie Hurup ; Styrishave, Bjarne ; Antignac, Jean-Philippe ; Le Bizec, Bruno ; Platel, Christian ; Hay-Schmidt, Anders ; Jensen, Tina Kold ; Lesné, Laurianne ; Mazaud-Guittot, Séverine ; Kristiansen, Karsten ; Brunak, Søren ; Kjaer, Michael ; Juul, Anders ; Jégou, Bernard. / Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism. I: Proceedings of the National Academy of Sciences of the United States of America. 2018 ; Bind 115, Nr. 4. s. E715-E724.

Bibtex

@article{e7b217372b42463994cdd09ecbd25a51,
title = "Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism",
abstract = "Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named {"}compensated hypogonadism,{"} a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.",
keywords = "Journal Article",
author = "Kristensen, {David M{\o}bjerg} and Christ{\`e}le Desdoits-Lethimonier and Mackey, {Abigail L} and Dalgaard, {Marlene Danner} and {De Masi}, Federico and Munkb{\o}l, {Cecilie Hurup} and Bjarne Styrishave and Jean-Philippe Antignac and {Le Bizec}, Bruno and Christian Platel and Anders Hay-Schmidt and Jensen, {Tina Kold} and Laurianne Lesn{\'e} and S{\'e}verine Mazaud-Guittot and Karsten Kristiansen and S{\o}ren Brunak and Michael Kjaer and Anders Juul and Bernard J{\'e}gou",
note = "Copyright {\circledC} 2018 the Author(s). Published by PNAS.",
year = "2018",
doi = "10.1073/pnas.1715035115",
language = "English",
volume = "115",
pages = "E715--E724",
journal = "National Academy of Sciences. Proceedings",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "4",

}

RIS

TY - JOUR

T1 - Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism

AU - Kristensen, David Møbjerg

AU - Desdoits-Lethimonier, Christèle

AU - Mackey, Abigail L

AU - Dalgaard, Marlene Danner

AU - De Masi, Federico

AU - Munkbøl, Cecilie Hurup

AU - Styrishave, Bjarne

AU - Antignac, Jean-Philippe

AU - Le Bizec, Bruno

AU - Platel, Christian

AU - Hay-Schmidt, Anders

AU - Jensen, Tina Kold

AU - Lesné, Laurianne

AU - Mazaud-Guittot, Séverine

AU - Kristiansen, Karsten

AU - Brunak, Søren

AU - Kjaer, Michael

AU - Juul, Anders

AU - Jégou, Bernard

N1 - Copyright © 2018 the Author(s). Published by PNAS.

PY - 2018

Y1 - 2018

N2 - Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.

AB - Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.

KW - Journal Article

U2 - 10.1073/pnas.1715035115

DO - 10.1073/pnas.1715035115

M3 - Journal article

VL - 115

SP - E715-E724

JO - National Academy of Sciences. Proceedings

JF - National Academy of Sciences. Proceedings

SN - 0027-8424

IS - 4

ER -

ID: 52377347