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Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival

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@article{9165feb0c8b8468ca987c93c9448f671,
title = "Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival",
abstract = "BACKGROUND: The purpose of this study was to examine the prevalence of human papillomavirus (HPV) in patients with head and neck squamous cell carcinoma of unknown primary (CUP).METHODS: All patients diagnosed with and treated for CUP between January 1, 2000, and June 1, 2011, at two Danish medical centers were included. All patients received a thorough diagnostic work-up, including FDG-PET, before being diagnosed as CUP. We determined the HPV status in all patients using a combination of HPV DNA PCR and p16 stain. In addition, clinical information on the study patients was retrieved from clinical records.RESULTS: Of the identified 60 patients with CUP, 13 were shown to be positive for HPV DNA, amounting to 22{\%} of the study population. In addition, we were able to show a clear disease-free and overall-survival benefit in the HPV-positive group, with a hazard ratio of 0.16 (95{\%} CI: 0.038-0.67) for over-all survival. This survival benefit was also apparent when adjusted for advanced age in a multivariate Cox regression analysis.CONCLUSION: A fairly large percentage of CUP cases are HPV-related, and because this is related to both the location and prognosis, we recommend HPV testing as part of the diagnostic work-up.",
author = "Jensen, {David Hebbelstrup} and Nora Hedback and Lena Specht and Estrid H{\o}gdall and Elo Andersen and Therkildsen, {Marianne Hamilton} and Lennart Friis-Hansen and Bodil Norrild and {von Buchwald}, Christian",
year = "2014",
doi = "10.1371/journal.pone.0110456",
language = "English",
volume = "9",
pages = "e110456",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

RIS

TY - JOUR

T1 - Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival

AU - Jensen, David Hebbelstrup

AU - Hedback, Nora

AU - Specht, Lena

AU - Høgdall, Estrid

AU - Andersen, Elo

AU - Therkildsen, Marianne Hamilton

AU - Friis-Hansen, Lennart

AU - Norrild, Bodil

AU - von Buchwald, Christian

PY - 2014

Y1 - 2014

N2 - BACKGROUND: The purpose of this study was to examine the prevalence of human papillomavirus (HPV) in patients with head and neck squamous cell carcinoma of unknown primary (CUP).METHODS: All patients diagnosed with and treated for CUP between January 1, 2000, and June 1, 2011, at two Danish medical centers were included. All patients received a thorough diagnostic work-up, including FDG-PET, before being diagnosed as CUP. We determined the HPV status in all patients using a combination of HPV DNA PCR and p16 stain. In addition, clinical information on the study patients was retrieved from clinical records.RESULTS: Of the identified 60 patients with CUP, 13 were shown to be positive for HPV DNA, amounting to 22% of the study population. In addition, we were able to show a clear disease-free and overall-survival benefit in the HPV-positive group, with a hazard ratio of 0.16 (95% CI: 0.038-0.67) for over-all survival. This survival benefit was also apparent when adjusted for advanced age in a multivariate Cox regression analysis.CONCLUSION: A fairly large percentage of CUP cases are HPV-related, and because this is related to both the location and prognosis, we recommend HPV testing as part of the diagnostic work-up.

AB - BACKGROUND: The purpose of this study was to examine the prevalence of human papillomavirus (HPV) in patients with head and neck squamous cell carcinoma of unknown primary (CUP).METHODS: All patients diagnosed with and treated for CUP between January 1, 2000, and June 1, 2011, at two Danish medical centers were included. All patients received a thorough diagnostic work-up, including FDG-PET, before being diagnosed as CUP. We determined the HPV status in all patients using a combination of HPV DNA PCR and p16 stain. In addition, clinical information on the study patients was retrieved from clinical records.RESULTS: Of the identified 60 patients with CUP, 13 were shown to be positive for HPV DNA, amounting to 22% of the study population. In addition, we were able to show a clear disease-free and overall-survival benefit in the HPV-positive group, with a hazard ratio of 0.16 (95% CI: 0.038-0.67) for over-all survival. This survival benefit was also apparent when adjusted for advanced age in a multivariate Cox regression analysis.CONCLUSION: A fairly large percentage of CUP cases are HPV-related, and because this is related to both the location and prognosis, we recommend HPV testing as part of the diagnostic work-up.

U2 - 10.1371/journal.pone.0110456

DO - 10.1371/journal.pone.0110456

M3 - Journal article

VL - 9

SP - e110456

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 11

ER -

ID: 44706665