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Rigshospitalet - en del af Københavns Universitetshospital
E-pub ahead of print

Human papillomavirus and squamous cell carcinoma of the urinary bladder: DaBlaCa-10 study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  1. Prognostic factors for relapse in patients with clinical stage I testicular cancer: protocol for a Danish nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Prognostic factors for relapse in patients with clinical stage I testicular cancer: protocol for a Danish nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Predictive value of AZGP1 following radical prostatectomy for prostate cancer: a cohort study and meta-analysis

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  4. 5hmC Level Predicts Biochemical Failure Following Radical Prostatectomy in Prostate Cancer Patients with ERG Negative Tumors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. The prognostic impact of incidental prostate cancer following radical cystoprostatectomy: a nationwide analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Kit Riegels Jørgensen
  • Søren Høyer
  • Jakob Kristian Jakobsen
  • Thor Knak Jensen
  • Niels Marcussen
  • Gitte Wrist Lam
  • Thomas Hasselager
  • Peter Ole Thind
  • Birgitte Grønkær Toft
  • Torben Steiniche
  • Jørgen Bjerggaard Jensen
Vis graf over relationer

OBJECTIVE: To evaluate a potential association between Human Papillomavirus (H.P.V.) and squamous cell carcinoma (S.C.C.) urinary bladder cancer (B.C.). Furthermore, the relation between p16INK4a, H.P.V. and B.C. was examined.

PATIENTS AND METHODS: Patients were included and divided into three groups based on the histological diagnosis of B.C.

SPECIMENS: An extensive exclusion was performed, including accepted casual risk factors for S.C.C. B.C., such as long-term use of catheters, cystolithiasis and Schistosoma hematobium infection. A total of 100 patients were included: 50 with pure S.C.C., 25 with urothelial carcinomas (U.C.) and 25 with squamous differentiation of U.C. (Sq.D.). The patients were operated at one of four major Danish hospitals in the period January 2005 to December 2016. Clinical information was collected from the medical records. Presence of H.P.V. was analyzed using the INNO-LiPA H.P.V. Genotyping Extra II. p16INK4a was analyzed using immunohistochemical (I.H.C.) staining. A p-value <0.05 was considered statistically significant.

RESULTS: An overall H.P.V. prevalence of 12/100 (12%) was observed. H.P.V. was demonstrated in 9/50 (18%) of the S.C.C.

PATIENTS: Overall, p16INK4a over-expression was observed in 52/100 (52%) patients. However, concomitant H.P.V. positivity and p16INK4a over-expression were observed in only 4/100 (4%) patients.

CONCLUSION: The presence of H.P.V. in one fifth of patients with S.C.C. B.C. was demonstrated. H.P.V. infection could have a significant association with S.C.C. B.C. without other known casual risk factors for S.C.C. B.C.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Urology
Sider (fra-til)e-pub
ISSN2168-1805
DOI
StatusE-pub ahead of print - 2019

ID: 56245976