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Human immunotypes impose selection on viral genotypes through viral epitope specificity

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Gabrielaite, M, Bennedbæk, M, Zucco, AG, Ekenberg, C, Murray, DD, Kan, VL, Touloumi, G, Vandekerckhove, L, Turner, D, Neaton, J, Lane, HC, Safo, S, Arenas-Pinto, A, Polizzotto, MN, Günthard, HF, Lundgren, JD, Marvig, RL & INSIGHT START trial group 2021, 'Human immunotypes impose selection on viral genotypes through viral epitope specificity', The Journal of infectious diseases, bind 224, nr. 12, s. 2053-2063. https://doi.org/10.1093/infdis/jiab253

APA

Gabrielaite, M., Bennedbæk, M., Zucco, A. G., Ekenberg, C., Murray, D. D., Kan, V. L., Touloumi, G., Vandekerckhove, L., Turner, D., Neaton, J., Lane, H. C., Safo, S., Arenas-Pinto, A., Polizzotto, M. N., Günthard, H. F., Lundgren, J. D., Marvig, R. L., & INSIGHT START trial group (2021). Human immunotypes impose selection on viral genotypes through viral epitope specificity. The Journal of infectious diseases, 224(12), 2053-2063. https://doi.org/10.1093/infdis/jiab253

CBE

Gabrielaite M, Bennedbæk M, Zucco AG, Ekenberg C, Murray DD, Kan VL, Touloumi G, Vandekerckhove L, Turner D, Neaton J, Lane HC, Safo S, Arenas-Pinto A, Polizzotto MN, Günthard HF, Lundgren JD, Marvig RL, INSIGHT START trial group. 2021. Human immunotypes impose selection on viral genotypes through viral epitope specificity. The Journal of infectious diseases. 224(12):2053-2063. https://doi.org/10.1093/infdis/jiab253

MLA

Vancouver

Author

Gabrielaite, Migle ; Bennedbæk, Marc ; Zucco, Adrian G ; Ekenberg, Christina ; Murray, Daniel D ; Kan, Virginia L ; Touloumi, Giota ; Vandekerckhove, Linos ; Turner, Dan ; Neaton, James ; Lane, H Clifford ; Safo, Sandra ; Arenas-Pinto, Alejandro ; Polizzotto, Mark N ; Günthard, Huldrych F ; Lundgren, Jens D ; Marvig, Rasmus L ; INSIGHT START trial group. / Human immunotypes impose selection on viral genotypes through viral epitope specificity. I: The Journal of infectious diseases. 2021 ; Bind 224, Nr. 12. s. 2053-2063.

Bibtex

@article{b5df23a7bf914c70a790b4104fd8c92e,
title = "Human immunotypes impose selection on viral genotypes through viral epitope specificity",
abstract = "BACKGROUND: Understanding the genetic interplay between human hosts and infectious pathogens is crucial for how we interpret virulence factors. Here, we tested for associations between HIV and host genetics, and interactive genetic effects on viral load (VL) in HIV-positive antiretroviral treatment-naive clinical trial participants.METHODS: HIV genomes were sequenced and the encoded amino acid (AA) variants were associated with VL, human single nucleotide polymorphisms (SNPs), and imputed HLA alleles using generalized linear models with Bonferroni correction.RESULTS: Human (388 501 SNPs) and HIV (3010 variants) genetic data were available for 2122 persons. Four HIV variants were associated with VL (P < 1.66 × 10-5). Twelve HIV variants were associated with a range of 1-512 human SNPs (P < 4.28 × 10-11). We found 46 associations between HLA alleles and HIV variants (P < 1.29 × 10-7). HIV variants and immunotypes when analyzed separately were associated with lower VL, whereas the opposite was true when analyzed in concert. Epitope binding predictions supported our observations.CONCLUSIONS: Our results show the importance of immunotype specificity on viral antigenic determinants, and the identified genetic interplay emphasizes that viral and human genetics should be studied in the context of each other.Clinical Trials Registration: NCT00867048.",
author = "Migle Gabrielaite and Marc Bennedb{\ae}k and Zucco, {Adrian G} and Christina Ekenberg and Murray, {Daniel D} and Kan, {Virginia L} and Giota Touloumi and Linos Vandekerckhove and Dan Turner and James Neaton and Lane, {H Clifford} and Sandra Safo and Alejandro Arenas-Pinto and Polizzotto, {Mark N} and G{\"u}nthard, {Huldrych F} and Lundgren, {Jens D} and Marvig, {Rasmus L} and {INSIGHT START trial group}",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2021",
month = dec,
day = "15",
doi = "10.1093/infdis/jiab253",
language = "English",
volume = "224",
pages = "2053--2063",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "University of Chicago Press",
number = "12",

}

RIS

TY - JOUR

T1 - Human immunotypes impose selection on viral genotypes through viral epitope specificity

AU - Gabrielaite, Migle

AU - Bennedbæk, Marc

AU - Zucco, Adrian G

AU - Ekenberg, Christina

AU - Murray, Daniel D

AU - Kan, Virginia L

AU - Touloumi, Giota

AU - Vandekerckhove, Linos

AU - Turner, Dan

AU - Neaton, James

AU - Lane, H Clifford

AU - Safo, Sandra

AU - Arenas-Pinto, Alejandro

AU - Polizzotto, Mark N

AU - Günthard, Huldrych F

AU - Lundgren, Jens D

AU - Marvig, Rasmus L

AU - INSIGHT START trial group

N1 - © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2021/12/15

Y1 - 2021/12/15

N2 - BACKGROUND: Understanding the genetic interplay between human hosts and infectious pathogens is crucial for how we interpret virulence factors. Here, we tested for associations between HIV and host genetics, and interactive genetic effects on viral load (VL) in HIV-positive antiretroviral treatment-naive clinical trial participants.METHODS: HIV genomes were sequenced and the encoded amino acid (AA) variants were associated with VL, human single nucleotide polymorphisms (SNPs), and imputed HLA alleles using generalized linear models with Bonferroni correction.RESULTS: Human (388 501 SNPs) and HIV (3010 variants) genetic data were available for 2122 persons. Four HIV variants were associated with VL (P < 1.66 × 10-5). Twelve HIV variants were associated with a range of 1-512 human SNPs (P < 4.28 × 10-11). We found 46 associations between HLA alleles and HIV variants (P < 1.29 × 10-7). HIV variants and immunotypes when analyzed separately were associated with lower VL, whereas the opposite was true when analyzed in concert. Epitope binding predictions supported our observations.CONCLUSIONS: Our results show the importance of immunotype specificity on viral antigenic determinants, and the identified genetic interplay emphasizes that viral and human genetics should be studied in the context of each other.Clinical Trials Registration: NCT00867048.

AB - BACKGROUND: Understanding the genetic interplay between human hosts and infectious pathogens is crucial for how we interpret virulence factors. Here, we tested for associations between HIV and host genetics, and interactive genetic effects on viral load (VL) in HIV-positive antiretroviral treatment-naive clinical trial participants.METHODS: HIV genomes were sequenced and the encoded amino acid (AA) variants were associated with VL, human single nucleotide polymorphisms (SNPs), and imputed HLA alleles using generalized linear models with Bonferroni correction.RESULTS: Human (388 501 SNPs) and HIV (3010 variants) genetic data were available for 2122 persons. Four HIV variants were associated with VL (P < 1.66 × 10-5). Twelve HIV variants were associated with a range of 1-512 human SNPs (P < 4.28 × 10-11). We found 46 associations between HLA alleles and HIV variants (P < 1.29 × 10-7). HIV variants and immunotypes when analyzed separately were associated with lower VL, whereas the opposite was true when analyzed in concert. Epitope binding predictions supported our observations.CONCLUSIONS: Our results show the importance of immunotype specificity on viral antigenic determinants, and the identified genetic interplay emphasizes that viral and human genetics should be studied in the context of each other.Clinical Trials Registration: NCT00867048.

U2 - 10.1093/infdis/jiab253

DO - 10.1093/infdis/jiab253

M3 - Journal article

C2 - 33974707

VL - 224

SP - 2053

EP - 2063

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 12

ER -

ID: 65482963