Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Human adipogenesis is associated with genome-wide DNA methylation and gene-expression changes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Introducing enteral feeding induces intestinal subclinical inflammation and respective chromatin changes in preterm pigs

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Dyslipidemia at diagnosis of childhood acute lymphoblastic leukemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Angiotensinogen promoter methylation predicts bevacizumab treatment response of patients with recurrent glioblastoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Epigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

AIM: To define the genomic distribution and function of DNA methylation changes during human adipogenesis.

METHODS: We isolated adipocyte-derived stem cells from 13 individuals and analyzed genome-wide DNA methylation and gene expression in cultured adipocyte-derived stem cells and mature adipocytes.

RESULTS: We observed altered DNA methylation of 11,947 CpG sites and altered expression of 11,830 transcripts after differentiation. De novo methylation was observed across all genomic elements. Co-existence of genes with both altered expression and DNA methylation was found in genes important for cell cycle and adipokine signaling.

CONCLUSION: Human adipogenesis is associated with significant DNA methylation changes across the entire genome and may impact regulation of cell cycle and adipokine signaling.

OriginalsprogEngelsk
TidsskriftEpigenomics
Vol/bind8
Udgave nummer12
Sider (fra-til)1601-1617
Antal sider17
ISSN1750-1911
DOI
StatusUdgivet - dec. 2016

ID: 49913935