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Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity: a Danish nationwide cohort study

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Harvard

Broccia, MM, de Knegt, VEVE, Mills, EHAEHA, Møller, ALAL, Gnesin, FF, Fischer, TKTK, Zylyftari, NN, Blomberg, SNSN, Andersen, MPMP, Schou, MM, Fosbøl, EE, Kragholm, KK, Christensen, HCHC, Polcwiartek, LBLB, Phelps, MM, Køber, LL & Torp-Pedersen, CC 2022, 'Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity: a Danish nationwide cohort study', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, bind 74, nr. 1, ciab340, s. 1-7. https://doi.org/10.1093/cid/ciab340

APA

Broccia, M. M., de Knegt, V. E. V. E., Mills, E. H. A. E. H. A., Møller, A. L. A. L., Gnesin, F. F., Fischer, T. K. T. K., Zylyftari, N. N., Blomberg, S. N. S. N., Andersen, M. P. M. P., Schou, M. M., Fosbøl, E. E., Kragholm, K. K., Christensen, H. C. H. C., Polcwiartek, L. B. L. B., Phelps, M. M., Køber, L. L., & Torp-Pedersen, C. C. (2022). Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity: a Danish nationwide cohort study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 74(1), 1-7. [ciab340]. https://doi.org/10.1093/cid/ciab340

CBE

Broccia MM, de Knegt VEVE, Mills EHAEHA, Møller ALAL, Gnesin FF, Fischer TKTK, Zylyftari NN, Blomberg SNSN, Andersen MPMP, Schou MM, Fosbøl EE, Kragholm KK, Christensen HCHC, Polcwiartek LBLB, Phelps MM, Køber LL, Torp-Pedersen CC. 2022. Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity: a Danish nationwide cohort study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 74(1):1-7. https://doi.org/10.1093/cid/ciab340

MLA

Vancouver

Author

Broccia, Marcella M ; de Knegt, Victoria Elizabeth V E ; Mills, Elisabeth Helen Anna E H A ; Møller, Amalie Lykkemark A L ; Gnesin, Filip F ; Fischer, Thea K T K ; Zylyftari, Nertila N ; Blomberg, Stig Nikolaj S N ; Andersen, Mikkel Porsborg M P ; Schou, Morten M ; Fosbøl, Emil E ; Kragholm, Kristian K ; Christensen, Helle Collatz H C ; Polcwiartek, Laura Bech L B ; Phelps, Matthew M ; Køber, Lars L ; Torp-Pedersen, Christian C. / Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity : a Danish nationwide cohort study. I: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 ; Bind 74, Nr. 1. s. 1-7.

Bibtex

@article{08ebb8168c094439b14b0977af357ba9,
title = "Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity: a Danish nationwide cohort study",
abstract = "BACKGROUND: Households are high-risk settings for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severity of coronavirus disease 2019 (COVID-19) is likely associated with the infectious dose of SARS-CoV-2 exposure. We therefore aimed to assess the association between SARS-CoV-2 exposure within households and COVID-19 severity.METHODS: We performed a Danish, nationwide, register-based, cohort study including laboratory-confirmed SARS-CoV-2-infected individuals from 22 February 2020 to 6 October 2020. Household exposure to SARS-CoV-2 was defined as having 1 individual test positive for SARS-CoV-2 within the household. Cox proportional hazards models were used to estimate the association between {"}critical COVID-19{"} within and between households with and without secondary cases.RESULTS: From 15 063 multiperson households, 19 773 SARS-CoV-2-positive individuals were included; 11 632 were categorized as index cases without any secondary household cases; 3431 as index cases with secondary cases, that is, 22.8% of multiperson households; and 4710 as secondary cases. Critical COVID-19 occurred in 2.9% of index cases living with no secondary cases, 4.9% of index cases with secondary cases, and 1.3% of secondary cases. The adjusted hazard ratio for critical COVID-19 among index cases vs secondary cases within the same household was 2.50 (95% confidence interval [CI], 1.88-3.34), 2.27 (95% CI, 1.77-2.93) for index cases in households with no secondary cases vs secondary cases, and 1.1 (95% CI, .93-1.30) for index cases with secondary cases vs index cases without secondary cases.CONCLUSIONS: We found no increased hazard ratio of critical COVID-19 among household members of infected SARS-CoV-2 index cases.",
keywords = "COVID-19, Cohort Studies, Denmark/epidemiology, Family Characteristics, Humans, SARS-CoV-2, transmission, viral load, death, corona, infectious dose",
author = "Broccia, {Marcella M} and {de Knegt}, {Victoria Elizabeth V E} and Mills, {Elisabeth Helen Anna E H A} and M{\o}ller, {Amalie Lykkemark A L} and Gnesin, {Filip F} and Fischer, {Thea K T K} and Zylyftari, {Nertila N} and Blomberg, {Stig Nikolaj S N} and Andersen, {Mikkel Porsborg M P} and Schou, {Morten M} and Fosb{\o}l, {Emil E} and Kragholm, {Kristian K} and Christensen, {Helle Collatz H C} and Polcwiartek, {Laura Bech L B} and Phelps, {Matthew M} and K{\o}ber, {Lars L} and Torp-Pedersen, {Christian C}",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2022",
month = jan,
day = "7",
doi = "10.1093/cid/ciab340",
language = "English",
volume = "74",
pages = "1--7",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "University of Chicago Press",
number = "1",

}

RIS

TY - JOUR

T1 - Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity

T2 - a Danish nationwide cohort study

AU - Broccia, Marcella M

AU - de Knegt, Victoria Elizabeth V E

AU - Mills, Elisabeth Helen Anna E H A

AU - Møller, Amalie Lykkemark A L

AU - Gnesin, Filip F

AU - Fischer, Thea K T K

AU - Zylyftari, Nertila N

AU - Blomberg, Stig Nikolaj S N

AU - Andersen, Mikkel Porsborg M P

AU - Schou, Morten M

AU - Fosbøl, Emil E

AU - Kragholm, Kristian K

AU - Christensen, Helle Collatz H C

AU - Polcwiartek, Laura Bech L B

AU - Phelps, Matthew M

AU - Køber, Lars L

AU - Torp-Pedersen, Christian C

N1 - © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2022/1/7

Y1 - 2022/1/7

N2 - BACKGROUND: Households are high-risk settings for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severity of coronavirus disease 2019 (COVID-19) is likely associated with the infectious dose of SARS-CoV-2 exposure. We therefore aimed to assess the association between SARS-CoV-2 exposure within households and COVID-19 severity.METHODS: We performed a Danish, nationwide, register-based, cohort study including laboratory-confirmed SARS-CoV-2-infected individuals from 22 February 2020 to 6 October 2020. Household exposure to SARS-CoV-2 was defined as having 1 individual test positive for SARS-CoV-2 within the household. Cox proportional hazards models were used to estimate the association between "critical COVID-19" within and between households with and without secondary cases.RESULTS: From 15 063 multiperson households, 19 773 SARS-CoV-2-positive individuals were included; 11 632 were categorized as index cases without any secondary household cases; 3431 as index cases with secondary cases, that is, 22.8% of multiperson households; and 4710 as secondary cases. Critical COVID-19 occurred in 2.9% of index cases living with no secondary cases, 4.9% of index cases with secondary cases, and 1.3% of secondary cases. The adjusted hazard ratio for critical COVID-19 among index cases vs secondary cases within the same household was 2.50 (95% confidence interval [CI], 1.88-3.34), 2.27 (95% CI, 1.77-2.93) for index cases in households with no secondary cases vs secondary cases, and 1.1 (95% CI, .93-1.30) for index cases with secondary cases vs index cases without secondary cases.CONCLUSIONS: We found no increased hazard ratio of critical COVID-19 among household members of infected SARS-CoV-2 index cases.

AB - BACKGROUND: Households are high-risk settings for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severity of coronavirus disease 2019 (COVID-19) is likely associated with the infectious dose of SARS-CoV-2 exposure. We therefore aimed to assess the association between SARS-CoV-2 exposure within households and COVID-19 severity.METHODS: We performed a Danish, nationwide, register-based, cohort study including laboratory-confirmed SARS-CoV-2-infected individuals from 22 February 2020 to 6 October 2020. Household exposure to SARS-CoV-2 was defined as having 1 individual test positive for SARS-CoV-2 within the household. Cox proportional hazards models were used to estimate the association between "critical COVID-19" within and between households with and without secondary cases.RESULTS: From 15 063 multiperson households, 19 773 SARS-CoV-2-positive individuals were included; 11 632 were categorized as index cases without any secondary household cases; 3431 as index cases with secondary cases, that is, 22.8% of multiperson households; and 4710 as secondary cases. Critical COVID-19 occurred in 2.9% of index cases living with no secondary cases, 4.9% of index cases with secondary cases, and 1.3% of secondary cases. The adjusted hazard ratio for critical COVID-19 among index cases vs secondary cases within the same household was 2.50 (95% confidence interval [CI], 1.88-3.34), 2.27 (95% CI, 1.77-2.93) for index cases in households with no secondary cases vs secondary cases, and 1.1 (95% CI, .93-1.30) for index cases with secondary cases vs index cases without secondary cases.CONCLUSIONS: We found no increased hazard ratio of critical COVID-19 among household members of infected SARS-CoV-2 index cases.

KW - COVID-19

KW - Cohort Studies

KW - Denmark/epidemiology

KW - Family Characteristics

KW - Humans

KW - SARS-CoV-2

KW - transmission

KW - viral load

KW - death

KW - corona

KW - infectious dose

UR - http://www.scopus.com/inward/record.url?scp=85118639712&partnerID=8YFLogxK

U2 - 10.1093/cid/ciab340

DO - 10.1093/cid/ciab340

M3 - Journal article

C2 - 33893489

VL - 74

SP - 1

EP - 7

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 1

M1 - ciab340

ER -

ID: 65156784