Harvard
Broccia, MM, de Knegt, VEVE, Mills, EHAEHA, Møller, ALAL, Gnesin, FF, Fischer, TKTK, Zylyftari, NN, Blomberg, SNSN, Andersen, MPMP, Schou, MM
, Fosbøl, EE, Kragholm, KK, Christensen, HCHC, Polcwiartek, LBLB, Phelps, MM
, Køber, LL & Torp-Pedersen, CC 2022, '
Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity: a Danish nationwide cohort study',
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, bind 74, nr. 1, ciab340, s. 1-7.
https://doi.org/10.1093/cid/ciab340
APA
Broccia, M. M., de Knegt, V. E. V. E., Mills, E. H. A. E. H. A., Møller, A. L. A. L., Gnesin, F. F., Fischer, T. K. T. K., Zylyftari, N. N., Blomberg, S. N. S. N., Andersen, M. P. M. P., Schou, M. M.
, Fosbøl, E. E., Kragholm, K. K., Christensen, H. C. H. C., Polcwiartek, L. B. L. B., Phelps, M. M.
, Køber, L. L., & Torp-Pedersen, C. C. (2022).
Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity: a Danish nationwide cohort study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
74(1), 1-7. [ciab340].
https://doi.org/10.1093/cid/ciab340
CBE
Broccia MM, de Knegt VEVE, Mills EHAEHA, Møller ALAL, Gnesin FF, Fischer TKTK, Zylyftari NN, Blomberg SNSN, Andersen MPMP, Schou MM
, Fosbøl EE, Kragholm KK, Christensen HCHC, Polcwiartek LBLB, Phelps MM
, Køber LL, Torp-Pedersen CC. 2022.
Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity: a Danish nationwide cohort study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 74(1):1-7.
https://doi.org/10.1093/cid/ciab340
MLA
Vancouver
Author
Broccia, Marcella M ; de Knegt, Victoria Elizabeth V E ; Mills, Elisabeth Helen Anna E H A ; Møller, Amalie Lykkemark A L ; Gnesin, Filip F ; Fischer, Thea K T K ; Zylyftari, Nertila N ; Blomberg, Stig Nikolaj S N ; Andersen, Mikkel Porsborg M P ; Schou, Morten M
; Fosbøl, Emil E ; Kragholm, Kristian K ; Christensen, Helle Collatz H C ; Polcwiartek, Laura Bech L B ; Phelps, Matthew M
; Køber, Lars L ; Torp-Pedersen, Christian C. /
Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity : a Danish nationwide cohort study. I:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 ; Bind 74, Nr. 1. s. 1-7.
Bibtex
@article{08ebb8168c094439b14b0977af357ba9,
title = "Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity: a Danish nationwide cohort study",
abstract = "BACKGROUND: Households are high-risk settings for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severity of coronavirus disease 2019 (COVID-19) is likely associated with the infectious dose of SARS-CoV-2 exposure. We therefore aimed to assess the association between SARS-CoV-2 exposure within households and COVID-19 severity.METHODS: We performed a Danish, nationwide, register-based, cohort study including laboratory-confirmed SARS-CoV-2-infected individuals from 22 February 2020 to 6 October 2020. Household exposure to SARS-CoV-2 was defined as having 1 individual test positive for SARS-CoV-2 within the household. Cox proportional hazards models were used to estimate the association between {"}critical COVID-19{"} within and between households with and without secondary cases.RESULTS: From 15 063 multiperson households, 19 773 SARS-CoV-2-positive individuals were included; 11 632 were categorized as index cases without any secondary household cases; 3431 as index cases with secondary cases, that is, 22.8% of multiperson households; and 4710 as secondary cases. Critical COVID-19 occurred in 2.9% of index cases living with no secondary cases, 4.9% of index cases with secondary cases, and 1.3% of secondary cases. The adjusted hazard ratio for critical COVID-19 among index cases vs secondary cases within the same household was 2.50 (95% confidence interval [CI], 1.88-3.34), 2.27 (95% CI, 1.77-2.93) for index cases in households with no secondary cases vs secondary cases, and 1.1 (95% CI, .93-1.30) for index cases with secondary cases vs index cases without secondary cases.CONCLUSIONS: We found no increased hazard ratio of critical COVID-19 among household members of infected SARS-CoV-2 index cases.",
keywords = "COVID-19, Cohort Studies, Denmark/epidemiology, Family Characteristics, Humans, SARS-CoV-2, transmission, viral load, death, corona, infectious dose",
author = "Broccia, {Marcella M} and {de Knegt}, {Victoria Elizabeth V E} and Mills, {Elisabeth Helen Anna E H A} and M{\o}ller, {Amalie Lykkemark A L} and Gnesin, {Filip F} and Fischer, {Thea K T K} and Zylyftari, {Nertila N} and Blomberg, {Stig Nikolaj S N} and Andersen, {Mikkel Porsborg M P} and Schou, {Morten M} and Fosb{\o}l, {Emil E} and Kragholm, {Kristian K} and Christensen, {Helle Collatz H C} and Polcwiartek, {Laura Bech L B} and Phelps, {Matthew M} and K{\o}ber, {Lars L} and Torp-Pedersen, {Christian C}",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2022",
month = jan,
day = "7",
doi = "10.1093/cid/ciab340",
language = "English",
volume = "74",
pages = "1--7",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "University of Chicago Press",
number = "1",
}
RIS
TY - JOUR
T1 - Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity
T2 - a Danish nationwide cohort study
AU - Broccia, Marcella M
AU - de Knegt, Victoria Elizabeth V E
AU - Mills, Elisabeth Helen Anna E H A
AU - Møller, Amalie Lykkemark A L
AU - Gnesin, Filip F
AU - Fischer, Thea K T K
AU - Zylyftari, Nertila N
AU - Blomberg, Stig Nikolaj S N
AU - Andersen, Mikkel Porsborg M P
AU - Schou, Morten M
AU - Fosbøl, Emil E
AU - Kragholm, Kristian K
AU - Christensen, Helle Collatz H C
AU - Polcwiartek, Laura Bech L B
AU - Phelps, Matthew M
AU - Køber, Lars L
AU - Torp-Pedersen, Christian C
N1 - © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
PY - 2022/1/7
Y1 - 2022/1/7
N2 - BACKGROUND: Households are high-risk settings for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severity of coronavirus disease 2019 (COVID-19) is likely associated with the infectious dose of SARS-CoV-2 exposure. We therefore aimed to assess the association between SARS-CoV-2 exposure within households and COVID-19 severity.METHODS: We performed a Danish, nationwide, register-based, cohort study including laboratory-confirmed SARS-CoV-2-infected individuals from 22 February 2020 to 6 October 2020. Household exposure to SARS-CoV-2 was defined as having 1 individual test positive for SARS-CoV-2 within the household. Cox proportional hazards models were used to estimate the association between "critical COVID-19" within and between households with and without secondary cases.RESULTS: From 15 063 multiperson households, 19 773 SARS-CoV-2-positive individuals were included; 11 632 were categorized as index cases without any secondary household cases; 3431 as index cases with secondary cases, that is, 22.8% of multiperson households; and 4710 as secondary cases. Critical COVID-19 occurred in 2.9% of index cases living with no secondary cases, 4.9% of index cases with secondary cases, and 1.3% of secondary cases. The adjusted hazard ratio for critical COVID-19 among index cases vs secondary cases within the same household was 2.50 (95% confidence interval [CI], 1.88-3.34), 2.27 (95% CI, 1.77-2.93) for index cases in households with no secondary cases vs secondary cases, and 1.1 (95% CI, .93-1.30) for index cases with secondary cases vs index cases without secondary cases.CONCLUSIONS: We found no increased hazard ratio of critical COVID-19 among household members of infected SARS-CoV-2 index cases.
AB - BACKGROUND: Households are high-risk settings for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severity of coronavirus disease 2019 (COVID-19) is likely associated with the infectious dose of SARS-CoV-2 exposure. We therefore aimed to assess the association between SARS-CoV-2 exposure within households and COVID-19 severity.METHODS: We performed a Danish, nationwide, register-based, cohort study including laboratory-confirmed SARS-CoV-2-infected individuals from 22 February 2020 to 6 October 2020. Household exposure to SARS-CoV-2 was defined as having 1 individual test positive for SARS-CoV-2 within the household. Cox proportional hazards models were used to estimate the association between "critical COVID-19" within and between households with and without secondary cases.RESULTS: From 15 063 multiperson households, 19 773 SARS-CoV-2-positive individuals were included; 11 632 were categorized as index cases without any secondary household cases; 3431 as index cases with secondary cases, that is, 22.8% of multiperson households; and 4710 as secondary cases. Critical COVID-19 occurred in 2.9% of index cases living with no secondary cases, 4.9% of index cases with secondary cases, and 1.3% of secondary cases. The adjusted hazard ratio for critical COVID-19 among index cases vs secondary cases within the same household was 2.50 (95% confidence interval [CI], 1.88-3.34), 2.27 (95% CI, 1.77-2.93) for index cases in households with no secondary cases vs secondary cases, and 1.1 (95% CI, .93-1.30) for index cases with secondary cases vs index cases without secondary cases.CONCLUSIONS: We found no increased hazard ratio of critical COVID-19 among household members of infected SARS-CoV-2 index cases.
KW - COVID-19
KW - Cohort Studies
KW - Denmark/epidemiology
KW - Family Characteristics
KW - Humans
KW - SARS-CoV-2
KW - transmission
KW - viral load
KW - death
KW - corona
KW - infectious dose
UR - http://www.scopus.com/inward/record.url?scp=85118639712&partnerID=8YFLogxK
U2 - 10.1093/cid/ciab340
DO - 10.1093/cid/ciab340
M3 - Journal article
C2 - 33893489
VL - 74
SP - 1
EP - 7
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 1
M1 - ciab340
ER -