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High dose intravenous iron, mineral homeostasis and intact FGF23 in normal and uremic rats

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@article{e8f4e1d05efb4d1f92f2819a2e42f548,
title = "High dose intravenous iron, mineral homeostasis and intact FGF23 in normal and uremic rats",
abstract = "High iron load might have a number of toxic effects in the organism. Recently intravenous (iv) iron has been proposed to induce elevation of fibroblast growth factor 23 (FGF23), hypophosphatemia and osteomalacia in iron deficient subjects. High levels of FGF23 are associated with increased mortality in the chronic kidney disease (CKD) population. CKD patients are often treated with iv iron therapy in order to maintain iron stores and erythropoietin responsiveness, also in the case of not being iron depleted. Therefore, the effect of a single high iv dose of two different iron preparations, iron isomaltoside 1000 (IIM) and ferric carboxymaltose (FCM), on plasma levels of FGF23 and phosphate was examined in normal and uremic iron repleted rats.",
author = "Eva Gravesen and Jacob Hofman-Bang and Mace, {Maria L.} and Ewa Lewin and Klaus Olgaard",
year = "2013",
doi = "10.1186/1471-2369-14-281",
language = "English",
volume = "14",
pages = "281",
journal = "BMC Nephrology",
issn = "1471-2369",
publisher = "BioMed Central Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - High dose intravenous iron, mineral homeostasis and intact FGF23 in normal and uremic rats

AU - Gravesen, Eva

AU - Hofman-Bang, Jacob

AU - Mace, Maria L.

AU - Lewin, Ewa

AU - Olgaard, Klaus

PY - 2013

Y1 - 2013

N2 - High iron load might have a number of toxic effects in the organism. Recently intravenous (iv) iron has been proposed to induce elevation of fibroblast growth factor 23 (FGF23), hypophosphatemia and osteomalacia in iron deficient subjects. High levels of FGF23 are associated with increased mortality in the chronic kidney disease (CKD) population. CKD patients are often treated with iv iron therapy in order to maintain iron stores and erythropoietin responsiveness, also in the case of not being iron depleted. Therefore, the effect of a single high iv dose of two different iron preparations, iron isomaltoside 1000 (IIM) and ferric carboxymaltose (FCM), on plasma levels of FGF23 and phosphate was examined in normal and uremic iron repleted rats.

AB - High iron load might have a number of toxic effects in the organism. Recently intravenous (iv) iron has been proposed to induce elevation of fibroblast growth factor 23 (FGF23), hypophosphatemia and osteomalacia in iron deficient subjects. High levels of FGF23 are associated with increased mortality in the chronic kidney disease (CKD) population. CKD patients are often treated with iv iron therapy in order to maintain iron stores and erythropoietin responsiveness, also in the case of not being iron depleted. Therefore, the effect of a single high iv dose of two different iron preparations, iron isomaltoside 1000 (IIM) and ferric carboxymaltose (FCM), on plasma levels of FGF23 and phosphate was examined in normal and uremic iron repleted rats.

U2 - 10.1186/1471-2369-14-281

DO - 10.1186/1471-2369-14-281

M3 - Journal article

VL - 14

SP - 281

JO - BMC Nephrology

JF - BMC Nephrology

SN - 1471-2369

IS - 1

ER -

ID: 42333152