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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Hepatocellular carcinoma in patients with chronic hepatitis C and cirrhosis in Denmark: a nationwide cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Low compliance with hepatocellular carcinoma screening guidelines in hepatitis B/C virus co-infected HIV patients with cirrhosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Historical epidemiology of hepatitis C virus (HCV) in selected countries

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Strategies to manage hepatitis C virus (HCV) disease burden

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Predictors of antiviral treatment initiation in hepatitis C virus-infected patients: a Danish cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Syphilitic hepatitis and neurosyphilis: an observational study of Danish HIV-infected individuals during a 13-year period

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Number of hospital contacts with alcohol problems predicts later risk of alcoholic liver cirrhosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Establishing a hepatitis C continuum of care among HIV/hepatitis C virus-coinfected individuals in EuroSIDA

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Minimally invasive assessment of hepatic function in children with indocyanine green elimination: a validation study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Prognostic molecular markers in pediatric liver disease - Are there any?

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

Cirrhosis in patients with chronic hepatitis C increases the risk of hepatocellular carcinoma (HCC) and surveillance with ultrasound (US) and alpha-fetoprotein (AFP) is recommended. This study aimed to estimate changes in the HCC incidence rate (IR) over time, HCC stage and prognosis, and AFP and US performed in patients with hepatitis C and cirrhosis. Eligible patients were identified in the Danish Database for Hepatitis B and C and data from national health registries and patient charts were obtained. Tumor stage was based on Barcelona-Clinic Liver Cancer stage, TNM classification and size and number of lesions combined into stage 0 - 3. We included 1,075 patients with hepatitis C and cirrhosis, free of HCC and liver transplant at baseline. During 4,988 person years (PY) 115 HCC cases were diagnosed. The HCC incidence rate increased from 0.8/100 PY [CI95% 0.4 - 1.5] in 2002-2003 to 2.9/100 PY [2.4 - 3.4] in 2012-2013. One-year cumulative incidence of at least one AFP or US was 53% among all patients. The positive predictive value of an AFP ≥ 20 ng mL(-1) was 17%. Twenty-three (21%) patients were diagnosed with early stage HCC (stage 0/1) and 84 (79%) with late stage. Median survival after HCC for early stage HCC disease was 30.1 months and 7.4 months for advanced HCC (stage 2/3). The incidence rate of HCC increased over time among patients with hepatitis C and cirrhosis in Denmark. Application of AFP and US was suboptimal and most patients were diagnosed with advanced HCC with a poor prognosis. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftJournal of Viral Hepatitis
Vol/bind25
Udgave nummer1
Sider (fra-til)47-55
ISSN1352-0504
DOI
StatusUdgivet - jan. 2018

ID: 51518682