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Hepatitis B and A virus antibodies in alcoholic steatosis and cirrhosis

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  • C Gluud
  • J Aldershvile
  • J Henriksen
  • P Kryger
  • L Mathiesen
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Sera from 74 alcoholics with cirrhosis and 63 alcoholics with steatosis were tested for antibody to hepatitis B surface antigen, to hepatitis B core antigen, and to hepatitis A virus by radioimmunoassay or enzyme-linked immunosorbent assay. No significant difference between the two groups of alcoholics could be found concerning the prevalence of these antibodies. The total group of patients had antibody to hepatitis B surface antigen or hepatitis B core antigen, or both, significantly (p less than 0.001) more often (26%) than sex- and age-matched controls (4%). No significant difference was found between patients and controls concerning the prevalence of antibody to hepatitis A virus (46% v 40%). In patients with cirrhosis, no correlation between wedged hepatic vein pressure or wedged-to-free hepatic vein pressure and any of the viral antibodies could be established. The present results suggest that hepatitis B virus does not play a major role in the progression of alcoholic liver disease, but longitudinal studies are needed to solve this problem. The reason for the increased prevalence of antibodies to hepatitis B virus in these patients is unknown.
OriginalsprogEngelsk
TidsskriftJournal of Clinical Pathology
Vol/bind35
Udgave nummer7
Sider (fra-til)693-7
Antal sider5
ISSN0021-9746
StatusUdgivet - jul. 1982

ID: 38929348