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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

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DOI

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OBJECTIVE: We investigated if Growth and Differentiation Factor 15 (GDF-15) can be used as a biomarker to distinguish patients with mitochondrial myopathy from patients with other myopathies.

METHODS: Serum GDF-15 was measured in 28 patients with mitochondrial disease, 24 with metabolic myopathies, 27 with muscular dystrophy and 21 healthy controls.

RESULTS AND CONCLUSIONS: Our findings indicate that elevated GDF-15 can distinguish patients with mitochondrial myopathy from other myopathies, including metabolic myopathies. This suggests that increases in GDF-15 is specific to respiratory chain dysfunction rather than general metabolic dysfunction or muscle defect.

OriginalsprogEngelsk
TidsskriftMitochondrion
Vol/bind50
Sider (fra-til)35-41
Antal sider7
ISSN1567-7249
DOI
StatusUdgivet - 26 okt. 2019

Bibliografisk note

Copyright © 2019 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

ID: 58350438