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Grouping of endocrine disrupting chemicals for mixture risk assessment - Evidence from a rat study

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Harvard

Christiansen, S, Axelstad, M, Scholze, M, Johansson, HKL, Hass, U, Mandrup, K, Frandsen, HL, Frederiksen, H, Isling, LK & Boberg, J 2020, 'Grouping of endocrine disrupting chemicals for mixture risk assessment - Evidence from a rat study' Environment International, bind 142, s. 105870. https://doi.org/10.1016/j.envint.2020.105870

APA

Christiansen, S., Axelstad, M., Scholze, M., Johansson, H. K. L., Hass, U., Mandrup, K., ... Boberg, J. (2020). Grouping of endocrine disrupting chemicals for mixture risk assessment - Evidence from a rat study. Environment International, 142, 105870. https://doi.org/10.1016/j.envint.2020.105870

CBE

Christiansen S, Axelstad M, Scholze M, Johansson HKL, Hass U, Mandrup K, Frandsen HL, Frederiksen H, Isling LK, Boberg J. 2020. Grouping of endocrine disrupting chemicals for mixture risk assessment - Evidence from a rat study. Environment International. 142:105870. https://doi.org/10.1016/j.envint.2020.105870

MLA

Vancouver

Author

Christiansen, Sofie ; Axelstad, Marta ; Scholze, Martin ; Johansson, Hanna K L ; Hass, Ulla ; Mandrup, Karen ; Frandsen, Henrik Lauritz ; Frederiksen, Hanne ; Isling, Louise Krag ; Boberg, Julie. / Grouping of endocrine disrupting chemicals for mixture risk assessment - Evidence from a rat study. I: Environment International. 2020 ; Bind 142. s. 105870.

Bibtex

@article{45e95e1a7c2548f4b93ba3a41adde405,
title = "Grouping of endocrine disrupting chemicals for mixture risk assessment - Evidence from a rat study",
abstract = "Exposure to mixtures of endocrine disrupting chemicals may contribute to the rising incidence of hormone-related diseases in humans. Real-life mixtures are complex, comprised of chemicals with mixed modes of action, and essential knowledge is often lacking on how to group such chemicals into cumulative assessment groups, which is an essential prerequisite to conduct a chemical mixture risk assessment. We investigated if mixtures of chemicals with diverse endocrine modes of action can cause mixture effects on hormone sensitive endpoints in developing and adult rat offspring after perinatal exposure. Wistar rats were exposed during pregnancy and lactation simultaneously to either bisphenol A and butylparaben (Emix), diethylhexyl phthalate and procymidone (Amix), or a mixture of all four substances (Totalmix). In male offspring, the anogenital distance was significantly reduced and nipple retention increased in animals exposed to Amix and Totalmix, and the mixture effects were well approximated by the dose addition model. The combination of Amix and Emix responded with more marked changes on these and other endocrine-sensitive endpoints than each binary mixture on its own. Sperm counts were reduced by all exposures. These experimental outcomes suggest that the grouping of chemicals for mixture risk assessment should be based on common health outcomes rather than only similar modes or mechanisms of action. Mechanistic-based approaches such as the concept of Adverse Outcome Pathway (AOP) can provide important guidance if both the information on shared target tissues and the information on shared mode/mechanism of action are taken into account.",
author = "Sofie Christiansen and Marta Axelstad and Martin Scholze and Johansson, {Hanna K L} and Ulla Hass and Karen Mandrup and Frandsen, {Henrik Lauritz} and Hanne Frederiksen and Isling, {Louise Krag} and Julie Boberg",
note = "Copyright {\circledC} 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2020",
month = "9",
doi = "10.1016/j.envint.2020.105870",
language = "English",
volume = "142",
pages = "105870",
journal = "Environmental International",
issn = "0160-4120",
publisher = "Pergamon",

}

RIS

TY - JOUR

T1 - Grouping of endocrine disrupting chemicals for mixture risk assessment - Evidence from a rat study

AU - Christiansen, Sofie

AU - Axelstad, Marta

AU - Scholze, Martin

AU - Johansson, Hanna K L

AU - Hass, Ulla

AU - Mandrup, Karen

AU - Frandsen, Henrik Lauritz

AU - Frederiksen, Hanne

AU - Isling, Louise Krag

AU - Boberg, Julie

N1 - Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2020/9

Y1 - 2020/9

N2 - Exposure to mixtures of endocrine disrupting chemicals may contribute to the rising incidence of hormone-related diseases in humans. Real-life mixtures are complex, comprised of chemicals with mixed modes of action, and essential knowledge is often lacking on how to group such chemicals into cumulative assessment groups, which is an essential prerequisite to conduct a chemical mixture risk assessment. We investigated if mixtures of chemicals with diverse endocrine modes of action can cause mixture effects on hormone sensitive endpoints in developing and adult rat offspring after perinatal exposure. Wistar rats were exposed during pregnancy and lactation simultaneously to either bisphenol A and butylparaben (Emix), diethylhexyl phthalate and procymidone (Amix), or a mixture of all four substances (Totalmix). In male offspring, the anogenital distance was significantly reduced and nipple retention increased in animals exposed to Amix and Totalmix, and the mixture effects were well approximated by the dose addition model. The combination of Amix and Emix responded with more marked changes on these and other endocrine-sensitive endpoints than each binary mixture on its own. Sperm counts were reduced by all exposures. These experimental outcomes suggest that the grouping of chemicals for mixture risk assessment should be based on common health outcomes rather than only similar modes or mechanisms of action. Mechanistic-based approaches such as the concept of Adverse Outcome Pathway (AOP) can provide important guidance if both the information on shared target tissues and the information on shared mode/mechanism of action are taken into account.

AB - Exposure to mixtures of endocrine disrupting chemicals may contribute to the rising incidence of hormone-related diseases in humans. Real-life mixtures are complex, comprised of chemicals with mixed modes of action, and essential knowledge is often lacking on how to group such chemicals into cumulative assessment groups, which is an essential prerequisite to conduct a chemical mixture risk assessment. We investigated if mixtures of chemicals with diverse endocrine modes of action can cause mixture effects on hormone sensitive endpoints in developing and adult rat offspring after perinatal exposure. Wistar rats were exposed during pregnancy and lactation simultaneously to either bisphenol A and butylparaben (Emix), diethylhexyl phthalate and procymidone (Amix), or a mixture of all four substances (Totalmix). In male offspring, the anogenital distance was significantly reduced and nipple retention increased in animals exposed to Amix and Totalmix, and the mixture effects were well approximated by the dose addition model. The combination of Amix and Emix responded with more marked changes on these and other endocrine-sensitive endpoints than each binary mixture on its own. Sperm counts were reduced by all exposures. These experimental outcomes suggest that the grouping of chemicals for mixture risk assessment should be based on common health outcomes rather than only similar modes or mechanisms of action. Mechanistic-based approaches such as the concept of Adverse Outcome Pathway (AOP) can provide important guidance if both the information on shared target tissues and the information on shared mode/mechanism of action are taken into account.

U2 - 10.1016/j.envint.2020.105870

DO - 10.1016/j.envint.2020.105870

M3 - Journal article

VL - 142

SP - 105870

JO - Environmental International

JF - Environmental International

SN - 0160-4120

ER -

ID: 60646586