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Graves' disease in two pregnancies complicated by fetal goitrous hypothyroidism: successful in utero treatment with levothyroxine

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@article{80a2013555c44ad9b17ea08d91a85d1e,
title = "Graves' disease in two pregnancies complicated by fetal goitrous hypothyroidism: successful in utero treatment with levothyroxine",
abstract = "Treatment of Graves' disease during pregnancy with antithyroid drugs (ATDs) poses a risk of inducing hypothyroidism and, thus, development of a goiter to the fetus. PATIENT FINDINGS: We report two patients referred to our department after discovery of a fetal goiter by ultrasound examination in the second trimester of pregnancy. The women receiving 400 mg/day propylthiouracil and 10 mg/day thiamizole, respectively, had thyrotropin and total thyroxine values within the normal reference range but a lowered free thyroxine level. Fetal blood sampling by cordocentesis revealed severe fetal hypothyroidism as the cause of goiter development. Reduction of maternal ATD dose and injection of levothyroxine intra-amniotically quickly reduced the goiter size, and both babies were born euthyroid and without goiters.",
author = "Sofie Bliddal and Rasmussen, {{\AA}se Krogh} and Karin Sundberg and Vibeke Brocks and Peter Skovbo and Ulla Feldt-Rasmussen",
year = "2011",
month = jan,
day = "1",
doi = "10.1089/thy.2010.0286",
language = "English",
volume = "21",
pages = "75--81",
journal = "Thyroid",
issn = "1050-7256",
publisher = "Mary Ann/Liebert, Inc. Publishers",
number = "1",

}

RIS

TY - JOUR

T1 - Graves' disease in two pregnancies complicated by fetal goitrous hypothyroidism: successful in utero treatment with levothyroxine

AU - Bliddal , Sofie

AU - Rasmussen, Åse Krogh

AU - Sundberg, Karin

AU - Brocks, Vibeke

AU - Skovbo, Peter

AU - Feldt-Rasmussen, Ulla

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Treatment of Graves' disease during pregnancy with antithyroid drugs (ATDs) poses a risk of inducing hypothyroidism and, thus, development of a goiter to the fetus. PATIENT FINDINGS: We report two patients referred to our department after discovery of a fetal goiter by ultrasound examination in the second trimester of pregnancy. The women receiving 400 mg/day propylthiouracil and 10 mg/day thiamizole, respectively, had thyrotropin and total thyroxine values within the normal reference range but a lowered free thyroxine level. Fetal blood sampling by cordocentesis revealed severe fetal hypothyroidism as the cause of goiter development. Reduction of maternal ATD dose and injection of levothyroxine intra-amniotically quickly reduced the goiter size, and both babies were born euthyroid and without goiters.

AB - Treatment of Graves' disease during pregnancy with antithyroid drugs (ATDs) poses a risk of inducing hypothyroidism and, thus, development of a goiter to the fetus. PATIENT FINDINGS: We report two patients referred to our department after discovery of a fetal goiter by ultrasound examination in the second trimester of pregnancy. The women receiving 400 mg/day propylthiouracil and 10 mg/day thiamizole, respectively, had thyrotropin and total thyroxine values within the normal reference range but a lowered free thyroxine level. Fetal blood sampling by cordocentesis revealed severe fetal hypothyroidism as the cause of goiter development. Reduction of maternal ATD dose and injection of levothyroxine intra-amniotically quickly reduced the goiter size, and both babies were born euthyroid and without goiters.

U2 - 10.1089/thy.2010.0286

DO - 10.1089/thy.2010.0286

M3 - Journal article

C2 - 21162688

VL - 21

SP - 75

EP - 81

JO - Thyroid

JF - Thyroid

SN - 1050-7256

IS - 1

ER -

ID: 31039567