Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
E-pub ahead of print

Glucocorticosteroids for sepsis in children. A protocol for a systematic review

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Patterns of cerebral tissue oxygen tension and cytoplasmic redox state in bacterial meningitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Delirium assessment in neuro-critically ill patients: A validation study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Dexmedetomidine for the management of delirium in critically ill patients-A protocol for a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Dexmedetomidine for the prevention of delirium in critically ill patients - A protocol for a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Exercise-Based Rehabilitation for Heart Failure: Cochrane Systematic Review, Meta-Analysis, and Trial Sequential Analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Plasma expanders for people with cirrhosis and large ascites treated with abdominal paracentesis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Radix Sophorae flavescentis versus other drugs or herbs for chronic hepatitis B

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Social skills training for attention deficit hyperactivity disorder (ADHD) in children aged 5 to 18 years

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

BACKGROUND: Sepsis is the primary diagnosis in more than 8% of all critically ill children and sepsis is among the ten leading causes of death in children <10 years. Glucocorticosteroids are currently recommended in septic children with fluid or catecholamine resistant refractory shock. Glucocorticosteroids are widely used for severe sepsis in paediatric intensive care units worldwide. However, the evidence on the clinical effects of glucocorticosteroids for sepsis in children is unclear.

METHODS: We will perform a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials. We will include randomised clinical trials assessing the effects of glucocorticosteroids vs placebo or no intervention as an add-on therapy to standard care for sepsis in children. For the assessment of harms, we will also include quasi-randomised studies and observational studies identified during our searches for randomised clinical trials.

DISCUSSION: This review will seek to assess whether glucocorticosteroids indeed have their therapeutic place in the standard treatment for sepsis in children.

OriginalsprogEngelsk
TidsskriftActa Anaesthesiologica Scandinavica
ISSN0001-5172
DOI
StatusE-pub ahead of print - 28 mar. 2019

Bibliografisk note

© 2019 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

ID: 56915212