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Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo

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@article{d360475853964ee3b541835a72ed8899,
title = "Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo",
abstract = "Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid hormones and ghrelin, but an effect of ghrelin on the human thyroid has never been investigated even though ghrelin receptors are present in the thyroid. The present study shows a ghrelin-induced decrease in the thyroid-stimulating hormone (TSH)-induced production of thyroglobulin and mRNA expression of thyroperoxidase in a primary culture of human thyroid cells obtained from paranodular tissue. Accordingly, a trend was noted for an inhibition of TSH-stimulated expression of the sodium-iodine symporter and the TSH-receptor. Thus, this study suggests an effect of ghrelin on human thyrocytes and thereby emphasizes the relevance of examining whether ghrelin also influences the metabolic homeostasis through altered thyroid hormone production.",
keywords = "Cell Differentiation, Cells, Cultured, Ghrelin, Humans, Receptors, Ghrelin, Receptors, Thyrotropin, Thyroglobulin, Thyroid Gland, Thyrotropin, Journal Article",
author = "Maria Barington and Brorson, {Marianne M{\o}ller} and Jacob Hofman-Bang and Rasmussen, {{\AA}se Krogh} and Birgitte Holst and Ulla Feldt-Rasmussen",
year = "2017",
doi = "10.1371/journal.pone.0184992",
language = "English",
volume = "12",
pages = "e0184992",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

RIS

TY - JOUR

T1 - Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo

AU - Barington, Maria

AU - Brorson, Marianne Møller

AU - Hofman-Bang, Jacob

AU - Rasmussen, Åse Krogh

AU - Holst, Birgitte

AU - Feldt-Rasmussen, Ulla

PY - 2017

Y1 - 2017

N2 - Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid hormones and ghrelin, but an effect of ghrelin on the human thyroid has never been investigated even though ghrelin receptors are present in the thyroid. The present study shows a ghrelin-induced decrease in the thyroid-stimulating hormone (TSH)-induced production of thyroglobulin and mRNA expression of thyroperoxidase in a primary culture of human thyroid cells obtained from paranodular tissue. Accordingly, a trend was noted for an inhibition of TSH-stimulated expression of the sodium-iodine symporter and the TSH-receptor. Thus, this study suggests an effect of ghrelin on human thyrocytes and thereby emphasizes the relevance of examining whether ghrelin also influences the metabolic homeostasis through altered thyroid hormone production.

AB - Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid hormones and ghrelin, but an effect of ghrelin on the human thyroid has never been investigated even though ghrelin receptors are present in the thyroid. The present study shows a ghrelin-induced decrease in the thyroid-stimulating hormone (TSH)-induced production of thyroglobulin and mRNA expression of thyroperoxidase in a primary culture of human thyroid cells obtained from paranodular tissue. Accordingly, a trend was noted for an inhibition of TSH-stimulated expression of the sodium-iodine symporter and the TSH-receptor. Thus, this study suggests an effect of ghrelin on human thyrocytes and thereby emphasizes the relevance of examining whether ghrelin also influences the metabolic homeostasis through altered thyroid hormone production.

KW - Cell Differentiation

KW - Cells, Cultured

KW - Ghrelin

KW - Humans

KW - Receptors, Ghrelin

KW - Receptors, Thyrotropin

KW - Thyroglobulin

KW - Thyroid Gland

KW - Thyrotropin

KW - Journal Article

U2 - 10.1371/journal.pone.0184992

DO - 10.1371/journal.pone.0184992

M3 - Journal article

VL - 12

SP - e0184992

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 9

ER -

ID: 52398867