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Germline Elongator mutations in Sonic Hedgehog medulloblastoma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. A roadmap for the Human Developmental Cell Atlas

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Repositioning of the global epicentre of non-optimal cholesterol

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Pan-cancer analysis of whole genomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

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  1. Is the health literacy of informal caregivers associated with the psychological outcomes of breast cancer survivors?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Antidepressant prescriptions and associated factors in men with prostate cancer and their female partners

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Risk of Depression After Radical Prostatectomy-A Nationwide Registry-based Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Prevalence of cognitive impairment and its relation to mental health in Danish lymphoma survivors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Sebastian M Waszak
  • Giles W Robinson
  • Brian L Gudenas
  • Kyle S Smith
  • Antoine Forget
  • Marija Kojic
  • Jesus Garcia-Lopez
  • Jennifer Hadley
  • Kayla V Hamilton
  • Emilie Indersie
  • Ivo Buchhalter
  • Jules Kerssemakers
  • Natalie Jäger
  • Tanvi Sharma
  • Tobias Rausch
  • Marcel Kool
  • Dominik Sturm
  • David T W Jones
  • Aksana Vasilyeva
  • Ruth G Tatevossian
  • Geoffrey Neale
  • Bérangère Lombard
  • Damarys Loew
  • Joy Nakitandwe
  • Michael Rusch
  • Daniel C Bowers
  • Anne Bendel
  • Sonia Partap
  • Murali Chintagumpala
  • John Crawford
  • Nicholas G Gottardo
  • Amy Smith
  • Christelle Dufour
  • Stefan Rutkowski
  • Tone Eggen
  • Finn Wesenberg
  • Kristina Kjaerheim
  • Maria Feychting
  • Birgitta Lannering
  • Joachim Schüz
  • Christoffer Johansen
  • Tina V Andersen
  • Martin Röösli
  • Claudia E Kuehni
  • Michael Grotzer
  • Marc Remke
  • Stéphanie Puget
  • Kristian W Pajtler
  • Till Milde
  • Olaf Witt
  • Marina Ryzhova
  • Andrey Korshunov
  • Brent A Orr
  • David W Ellison
  • Laurence Brugieres
  • Peter Lichter
  • Kim E Nichols
  • Amar Gajjar
  • Brandon J Wainwright
  • Olivier Ayrault
  • Jan O Korbel
  • Paul A Northcott
  • Stefan M Pfister
Vis graf over relationer

Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5 to 10% of cancer diagnoses in children1,2, and genetic events that cooperate with known somatic driver events are poorly understood. Pathogenic germline variants in established cancer predisposition genes have been recently identified in 5% of patients with the malignant brain tumour medulloblastoma3. Here, by analysing all protein-coding genes, we identify and replicate rare germline loss-of-function variants across ELP1 in 14% of paediatric patients with the medulloblastoma subgroup Sonic Hedgehog (MBSHH). ELP1 was the most common medulloblastoma predisposition gene and increased the prevalence of genetic predisposition to 40% among paediatric patients with MBSHH. Parent-offspring and pedigree analyses identified two families with a history of paediatric medulloblastoma. ELP1-associated medulloblastomas were restricted to the molecular SHHα subtype4 and characterized by universal biallelic inactivation of ELP1 owing to somatic loss of chromosome arm 9q. Most ELP1-associated medulloblastomas also exhibited somatic alterations in PTCH1, which suggests that germline ELP1 loss-of-function variants predispose individuals to tumour development in combination with constitutive activation of SHH signalling. ELP1 is the largest subunit of the evolutionarily conserved Elongator complex, which catalyses translational elongation through tRNA modifications at the wobble (U34) position5,6. Tumours from patients with ELP1-associated MBSHH were characterized by a destabilized Elongator complex, loss of Elongator-dependent tRNA modifications, codon-dependent translational reprogramming, and induction of the unfolded protein response, consistent with loss of protein homeostasis due to Elongator deficiency in model systems7-9. Thus, genetic predisposition to proteome instability may be a determinant in the pathogenesis of paediatric brain cancers. These results support investigation of the role of protein homeostasis in other cancer types and potential for therapeutic interference.

OriginalsprogEngelsk
TidsskriftNature
Vol/bind580
Udgave nummer7803
Sider (fra-til)396-401
Antal sider6
ISSN0028-0836
DOI
StatusUdgivet - 16 apr. 2020

ID: 61824707