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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Genome-wide high-density SNP linkage search for glioma susceptibility loci: results from the Gliogene Consortium

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    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for Glioma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A large-cohort, longitudinal study determines pre-cancer disease routes across different cancer types

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  4. Genetic data from nearly 63,000 women of European descent predicts DNA methylation biomarkers and epithelial ovarian cancer risk

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Clinical and histopathological predictors of outcome in malignant meningioma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Molecular Characterization of the Danish Prion Diseases Cohort With Special Emphasis on Rare and Unique Cases

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  • Sanjay Shete
  • Ching C Lau
  • Richard S Houlston
  • Elizabeth B Claus
  • Jill Barnholtz-Sloan
  • Rose Lai
  • Dora Il'yasova
  • Joellen Schildkraut
  • Siegal Sadetzki
  • Christoffer Johansen
  • Jonine L Bernstein
  • Sara H Olson
  • Robert B Jenkins
  • Ping Yang
  • Nicholas A Vick
  • Margaret Wrensch
  • Faith G Davis
  • Bridget J McCarthy
  • Eastwood Hon-chiu Leung
  • Caleb Davis
  • Rita Cheng
  • Fay J Hosking
  • Georgina N Armstrong
  • Yanhong Liu
  • Robert K Yu
  • Roger Henriksson
  • Beatrice S Melin
  • Melissa L Bondy
  • Gliogene Consortium
  • Helle Broholm
Vis graf over relationer
Gliomas, which generally have a poor prognosis, are the most common primary malignant brain tumors in adults. Recent genome-wide association studies have shown that inherited susceptibility plays a role in the development of glioma. Although first-degree relatives of patients exhibit a two-fold increased risk of glioma, the search for susceptibility loci in familial forms of the disease has been challenging because the disease is relatively rare, fatal, and heterogeneous, making it difficult to collect sufficient biosamples from families for statistical power. To address this challenge, the Genetic Epidemiology of Glioma International Consortium (Gliogene) was formed to collect DNA samples from families with two or more cases of histologically confirmed glioma. In this study, we present results obtained from 46 U.S. families in which multipoint linkage analyses were undertaken using nonparametric (model-free) methods. After removal of high linkage disequilibrium single-nucleotide polymorphism, we obtained a maximum nonparametric linkage score (NPL) of 3.39 (P = 0.0005) at 17q12-21.32 and the Z-score of 4.20 (P = 0.000007). To replicate our findings, we genotyped 29 independent U.S. families and obtained a maximum NPL score of 1.26 (P = 0.008) and the Z-score of 1.47 (P = 0.035). Accounting for the genetic heterogeneity using the ordered subset analysis approach, the combined analyses of 75 families resulted in a maximum NPL score of 3.81 (P = 0.00001). The genomic regions we have implicated in this study may offer novel insights into glioma susceptibility, focusing future work to identify genes that cause familial glioma.
OriginalsprogEngelsk
TidsskriftCancer Research
Vol/bind71
Udgave nummer24
Sider (fra-til)7568-75
Antal sider8
ISSN0008-5472
DOI
StatusUdgivet - 2011

ID: 33252907