Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Ultraviolet radiation drives mutations in a subset of mucosal melanomas

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Cytoplasmic mRNPs revisited: Singletons and condensates

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Elevated miR-9 in Cerebrospinal Fluid Is Associated with Poor Functional Outcome After Subarachnoid Hemorrhage

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Breast cancer survival in Nordic BRCA2 mutation carriers-unconventional association with oestrogen receptor status

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • EMBRACE Collaborators
Vis graf over relationer

Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.

OriginalsprogEngelsk
TidsskriftNature Communications
Vol/bind10
Udgave nummer1
Sider (fra-til)1741
ISSN2041-1723
DOI
StatusUdgivet - 15 apr. 2019

ID: 59010826