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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

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  • International Headache Genetics Consortium
Vis graf over relationer

Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2, CACNA1A and MPPED2), two that seem specific for migraine without aura (near SPINK2 and near FECH) and nine that increase susceptibility for migraine regardless of subtype. The new risk loci include genes encoding recent migraine-specific drug targets, namely calcitonin gene-related peptide (CALCA/CALCB) and serotonin 1F receptor (HTR1F). Overall, genomic annotations among migraine-associated variants were enriched in both vascular and central nervous system tissue/cell types, supporting unequivocally that neurovascular mechanisms underlie migraine pathophysiology.

OriginalsprogEngelsk
TidsskriftNature Genetics
Vol/bind54
Udgave nummer2
Sider (fra-til)152-160
Antal sider9
ISSN1061-4036
DOI
StatusUdgivet - 2022

Bibliografisk note

© 2022. The Author(s).

ID: 74335743