Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Genetic determinants of blood pressure traits are associated with carotid arterial thickening and plaque formation in patients with type 2 diabetes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. The association of celiac disease and allergic disease in a general adult population

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • CIMT Trial Group 10
Vis graf over relationer

OBJECTIVES: The aim of this study is to explore the contribution of genetically driven cardiometabolic risk factors for development of carotid arterial thickening in patients with type 2 diabetes.

METHODS: In total, 12 genetic risk scores for blood pressure, blood lipids and glycaemic traits were constructed. The genetic risk scores were tested for association with carotid intima-media thickness and plaques in patients with type 2 diabetes ( n = 401) and in non-diabetic individuals ( n = 648) and for association with glucose levels in two population-based cohorts ( n = 1328 and n = 6161).

RESULTS: In patients with type 2 diabetes, the genetic risk scores for pulse pressure were positively associated with plaque formation ( β = 0.036 ± 0.01 standard deviation/allele, p = 0.003). The genetic risk score for diastolic blood pressure was negatively associated with carotid intima-media thickness ( β = -0.037 ± 0.01 standard deviation/allele, p = 0.005), although not significant after correction for multiple testing ( p < 0.0042). In a meta-analysis of individuals with and without type 2 diabetes, the high-density lipoprotein genetic risk scores showed a trend towards an inverse association with carotid intima-media thickness and plaques, while the low-density lipoprotein genetic risk scores showed a trend towards a positive association with plaque formation but did reach the statistical threshold.

CONCLUSION: Genetic loci for pulse pressure are associated with plaque formation among patients with type 2 diabetes, suggesting an underlying genetic contribution to arterial stiffening and atherosclerosis.

OriginalsprogEngelsk
TidsskriftDiabetes and Vascular Disease Research
Vol/bind16
Udgave nummer1
Sider (fra-til)13-21
Antal sider9
ISSN1479-1641
DOI
StatusUdgivet - jan. 2019

ID: 56663908