Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Gender differences in sudden cardiac death in the young-a nationwide study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Incidence of heart valve disease in women treated with the ergot-derived dopamine agonist bromocriptine

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cardiovascular risk in patients with and without diabetes presenting with chronic coronary syndrome in 2004-2016

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Non-diagnostic autopsy findings in sudden unexplained death victims

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. High incidence of discrepancies in new Siemens assay - A comparison of cardiac troponin I assays

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Severity of anaemia and association with all-cause mortality in patients with medically managed left-sided endocarditis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Randomized Controlled Trial of Tesomet for Weight Loss in Hypothalamic Obesity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Acute symptoms in SARS-CoV-2 positive adolescents aged 15-18 years - Results from a Danish national cross-sectional survey study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Hitherto, sudden cardiac death (SCD) in the young has been described with no distinction between genders. SCD occurs more often in men (SCDm) than women (SCDw), but this disparity is not understood and has not been investigated systematically in a nationwide setting. Our objective was to report gender differences in SCD in the young in a nationwide (Denmark) setting.

METHODS: All deaths in persons aged 1-35 years nationwide in Denmark between 2000 and 2009 were included. Death certificates and autopsy reports were obtained. The extensive health care registries in Denmark were used to investigate any known disease prior to death. SCDw were compared to SCDm.

RESULTS: During the 10-year study period there were a total of 8756 deaths in 23.7 million person-years. In total, 635 deaths were SCD. SCDw constituted 205 deaths (32%). Women had a higher proportion of witnessed deaths (51 vs. 41%, p = 0.02) and died less often in a public place (16 vs. 26%, p = 0.01). Age at death, ratios of autopsies and sudden unexplained deaths, and comorbidities, did not differ. Causes of SCD were largely comparable between genders. The incidence rate of SCDw was half of that of SCDm (1.8 vs. 3.6 per 100,000 person-years, incidence rate ratio 2.0 (95% CI 1.7-2.4), p < 0.01).

CONCLUSIONS: Incidence rate ratio of SCDm vs SCDw is 2. Young SCDw and SCDm are equally investigated, have comparable comorbidity, and causes of SCD. SCD due to potentially inherited cardiac diseases is less often in young women and could reflect a protection of female gender.

OriginalsprogEngelsk
TidsskriftBMC Cardiovascular Disorders
Vol/bind17
Udgave nummer1
Sider (fra-til)e19
ISSN1471-2261
DOI
StatusUdgivet - 7 jan. 2017

ID: 51751894