Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Further Controversies About Brain Tissue Oxygenation Pressure-Reactivity After Traumatic Brain Injury

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Autonomic Dysfunction in Guillain-Barré Syndrome Puts Patients at Risk

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  2. What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Which Spreading Depolarizations Are Deleterious To Brain Tissue?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Continuous EEG Monitoring in a Consecutive Patient Cohort with Sepsis and Delirium

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Neurostereologic Lesion Volumes and Spreading Depolarizations in Severe Traumatic Brain Injury Patients: A Pilot Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Clinical and histopathological predictors of outcome in malignant meningioma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Long-Term Effect of Decompressive Craniectomy on Intracranial Pressure and Possible Implications for Intracranial Fluid Movements

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Telemetric intracranial pressure monitoring in children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. B waves: a systematic review of terminology, characteristics, and analysis methods

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

BACKGROUND: Continuous monitoring of cerebral autoregulation is considered clinically useful due to its ability to warn against brain ischemic insults, which may translate to a relationship with adverse outcome. It is typically performed using the pressure reactivity index (PRx) based on mean arterial pressure and intracranial pressure. A new ORx index based on brain tissue oxygenation and cerebral perfusion pressure (CPP) has been proposed that similarly allows for evaluation of cerebrovascular reactivity. Conflicting results exist concerning its clinical utility.

METHODS: Retrospective analysis was performed in 85 patients with traumatic brain injury (TBI). ORx was calculated using three time windows of 5, 20, and 60 min. Correlation coefficients and individual "optimal CPP" (CPPopt) were calculated using both PRx and ORx, and relation to patient outcome investigated.

RESULTS: Correlation coefficients for all comparisons between PRx and ORx indicated poor association between these indices (range from -0.04 to 0.07). PRx was significantly lower in patients with good outcome (p = 0.01), while none of the ORx indices proved to be significantly different in the two outcome groups. Higher mortality related to average CPP < CPPopt was found regardless of which index was used to calculate CPPopt.

CONCLUSION: In the TBI setting, ORx does not appear to correlate with vascular pressure reactivity as assessed with PRx. Its potential use for individualizing CPP thresholds remains unclear.

OriginalsprogEngelsk
TidsskriftNeurocritical Care
Vol/bind28
Udgave nummer2
Sider (fra-til)162-168
ISSN1541-6933
DOI
StatusUdgivet - 2018

ID: 52572450