Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Functional neuroimaging of recovery from motor conversion disorder: A case report

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Validity and reliability of extrastriatal [11C]raclopride binding quantification in the living human brain

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Optimization of preprocessing strategies in Positron Emission Tomography (PET) neuroimaging: A [11C]DASB PET study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Comparing fully automated state-of-the-art cerebellum parcellation from magnetic resonance images

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Men with high serotonin 1B receptor binding respond to provocations with heightened amygdala reactivity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Performance of five research-domain automated WM lesion segmentation methods in a multi-center MS study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Early Intrathecal T Helper 17.1 Cell Activity in Huntington Disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Intoxicationer og ernæringsdeficit

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiUndervisning

  3. Klinisk Neurologi og Neurokirurgi

    Publikation: Bog/antologi/afhandling/rapportBogUndervisning

  4. Author response: Nationwide prevalence and incidence study of neuromyelitis optica spectrum disorder in Denmark

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  5. Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

A patient with motor conversion disorder presented with a functional paresis of the left hand. After exclusion of structural brain damage, she was repeatedly examined with whole-brain functional magnetic resonance imaging, while she performed visually paced finger-tapping tasks. The dorsal premotor cortex showed a bilateral deactivation in the acute-subacute phase. Recovery from unilateral hand paresis was associated with a gradual increase in task-based activation of the dorsal premotor cortex bilaterally. The right medial prefrontal cortex displayed the opposite pattern, showing initial task-based activation that gradually diminished with recovery. The inverse dynamics of premotor and medial prefrontal activity over time were found during unimanual finger-tapping with the affected and non-affected hand as well as during bimanual finger-tapping. These observations suggest that reduced premotor and increased medial prefrontal activity reflect an effector-independent cortical dysfunction in conversion paresis which gradually disappears in parallel with clinical remission of paresis. The results link the medial prefrontal and dorsal premotor areas to the generation of intentional actions. We hypothesise that an excessive 'veto' signal generated in medial prefrontal cortex along with decreased premotor activity might constitute the functional substrate of conversion disorder. This notion warrants further examination in a larger group of affected patients.

OriginalsprogEngelsk
TidsskriftNeuroImage
Vol/bind190
Sider (fra-til)269-274
Antal sider6
ISSN1053-8119
DOI
StatusUdgivet - 15 apr. 2019

ID: 58702054