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Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation

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Harvard

Mohanakumar, S, Kelly, B, Turquetto, ALR, Alstrup, M, Amato, LP, Barnabe, MSR, Silveira, JBD, Amaral, F, Manso, PH, Jatene, MB & Hjortdal, VE 2021, 'Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation', Physiological Reports, bind 9, nr. 11, e14862, s. e14862. https://doi.org/10.14814/phy2.14862

APA

Mohanakumar, S., Kelly, B., Turquetto, A. L. R., Alstrup, M., Amato, L. P., Barnabe, M. S. R., Silveira, J. B. D., Amaral, F., Manso, P. H., Jatene, M. B., & Hjortdal, V. E. (2021). Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation. Physiological Reports, 9(11), e14862. [e14862]. https://doi.org/10.14814/phy2.14862

CBE

Mohanakumar S, Kelly B, Turquetto ALR, Alstrup M, Amato LP, Barnabe MSR, Silveira JBD, Amaral F, Manso PH, Jatene MB, Hjortdal VE. 2021. Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation. Physiological Reports. 9(11):e14862. https://doi.org/10.14814/phy2.14862

MLA

Vancouver

Mohanakumar S, Kelly B, Turquetto ALR, Alstrup M, Amato LP, Barnabe MSR o.a. Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation. Physiological Reports. 2021 jun;9(11):e14862. e14862. https://doi.org/10.14814/phy2.14862

Author

Mohanakumar, Sheyanth ; Kelly, Benjamin ; Turquetto, Aida Luiza Ribeiro ; Alstrup, Mathias ; Amato, Luciana Patrick ; Barnabe, Milena Schiezari Ru ; Silveira, João Bruno Dias ; Amaral, Fernando ; Manso, Paulo Henrique ; Jatene, Marcelo Biscegli ; Hjortdal, Vibeke Elisabeth. / Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation. I: Physiological Reports. 2021 ; Bind 9, Nr. 11. s. e14862.

Bibtex

@article{49ab06e9fed7473dab3af7e3a36da453,
title = "Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation",
abstract = "BACKGROUND: Lymphatic abnormalities play a role in effusions in individuals with a Fontan circulation. Recent results using near-infrared fluorescence imaging disclosed an increased contraction frequency of lymphatic vessels in Fontan patients compared to healthy controls. It is proposed that the elevated lymphatic pumping seen in the Fontan patients is necessary to maintain habitual interstitial fluid balance. Hyperthermia has previously been used as a tool for lymphatic stress test. By increasing fluid filtration in the capillary bed, the lymphatic workload and contraction frequency are increased accordingly. Using near-infrared fluorescence imaging, the lymphatic functional reserve capacity in Fontan patients were explored with a lymphatic stress test.METHODS: Fontan patients (n = 33) were compared to a group of 15 healthy individuals of equal age, weight, and gender. The function of the superficial lymphatic vessels in the lower leg during rest and after inducing hyperthermia was investigated, using near-infrared fluorescence imaging.RESULTS: Baseline values in the Fontan patients showed a 57% higher contraction frequency compared to the healthy controls (0.4 ± 0.3 min-1 vs. 0.3 ± 0.2 min-1 , p = 0.0445). After inducing stress on the lymphatic vessels with hyperthermia the ability to increase contraction frequency was decreased in the Fontan patients compared to the controls (0.6 ± 0.5 min-1 vs. 1.2 ± 0.8 min-1 , p = 0.0102).CONCLUSIONS: Fontan patients had a higher lymphatic contraction frequency during normal circumstances. In the Fontan patients, the hyperthermia response is dampened indicating that the functional lymphatic reserve capacity is depressed. This diminished reserve capacity could be part of the explanation as to why some Fontan patients develop late-onset lymphatic complications.",
author = "Sheyanth Mohanakumar and Benjamin Kelly and Turquetto, {Aida Luiza Ribeiro} and Mathias Alstrup and Amato, {Luciana Patrick} and Barnabe, {Milena Schiezari Ru} and Silveira, {Jo{\~a}o Bruno Dias} and Fernando Amaral and Manso, {Paulo Henrique} and Jatene, {Marcelo Biscegli} and Hjortdal, {Vibeke Elisabeth}",
note = "{\textcopyright} 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.",
year = "2021",
month = jun,
doi = "10.14814/phy2.14862",
language = "English",
volume = "9",
pages = "e14862",
journal = "Physiological Reports",
issn = "2051-817X",
publisher = "John Wiley and Sons Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation

AU - Mohanakumar, Sheyanth

AU - Kelly, Benjamin

AU - Turquetto, Aida Luiza Ribeiro

AU - Alstrup, Mathias

AU - Amato, Luciana Patrick

AU - Barnabe, Milena Schiezari Ru

AU - Silveira, João Bruno Dias

AU - Amaral, Fernando

AU - Manso, Paulo Henrique

AU - Jatene, Marcelo Biscegli

AU - Hjortdal, Vibeke Elisabeth

N1 - © 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

PY - 2021/6

Y1 - 2021/6

N2 - BACKGROUND: Lymphatic abnormalities play a role in effusions in individuals with a Fontan circulation. Recent results using near-infrared fluorescence imaging disclosed an increased contraction frequency of lymphatic vessels in Fontan patients compared to healthy controls. It is proposed that the elevated lymphatic pumping seen in the Fontan patients is necessary to maintain habitual interstitial fluid balance. Hyperthermia has previously been used as a tool for lymphatic stress test. By increasing fluid filtration in the capillary bed, the lymphatic workload and contraction frequency are increased accordingly. Using near-infrared fluorescence imaging, the lymphatic functional reserve capacity in Fontan patients were explored with a lymphatic stress test.METHODS: Fontan patients (n = 33) were compared to a group of 15 healthy individuals of equal age, weight, and gender. The function of the superficial lymphatic vessels in the lower leg during rest and after inducing hyperthermia was investigated, using near-infrared fluorescence imaging.RESULTS: Baseline values in the Fontan patients showed a 57% higher contraction frequency compared to the healthy controls (0.4 ± 0.3 min-1 vs. 0.3 ± 0.2 min-1 , p = 0.0445). After inducing stress on the lymphatic vessels with hyperthermia the ability to increase contraction frequency was decreased in the Fontan patients compared to the controls (0.6 ± 0.5 min-1 vs. 1.2 ± 0.8 min-1 , p = 0.0102).CONCLUSIONS: Fontan patients had a higher lymphatic contraction frequency during normal circumstances. In the Fontan patients, the hyperthermia response is dampened indicating that the functional lymphatic reserve capacity is depressed. This diminished reserve capacity could be part of the explanation as to why some Fontan patients develop late-onset lymphatic complications.

AB - BACKGROUND: Lymphatic abnormalities play a role in effusions in individuals with a Fontan circulation. Recent results using near-infrared fluorescence imaging disclosed an increased contraction frequency of lymphatic vessels in Fontan patients compared to healthy controls. It is proposed that the elevated lymphatic pumping seen in the Fontan patients is necessary to maintain habitual interstitial fluid balance. Hyperthermia has previously been used as a tool for lymphatic stress test. By increasing fluid filtration in the capillary bed, the lymphatic workload and contraction frequency are increased accordingly. Using near-infrared fluorescence imaging, the lymphatic functional reserve capacity in Fontan patients were explored with a lymphatic stress test.METHODS: Fontan patients (n = 33) were compared to a group of 15 healthy individuals of equal age, weight, and gender. The function of the superficial lymphatic vessels in the lower leg during rest and after inducing hyperthermia was investigated, using near-infrared fluorescence imaging.RESULTS: Baseline values in the Fontan patients showed a 57% higher contraction frequency compared to the healthy controls (0.4 ± 0.3 min-1 vs. 0.3 ± 0.2 min-1 , p = 0.0445). After inducing stress on the lymphatic vessels with hyperthermia the ability to increase contraction frequency was decreased in the Fontan patients compared to the controls (0.6 ± 0.5 min-1 vs. 1.2 ± 0.8 min-1 , p = 0.0102).CONCLUSIONS: Fontan patients had a higher lymphatic contraction frequency during normal circumstances. In the Fontan patients, the hyperthermia response is dampened indicating that the functional lymphatic reserve capacity is depressed. This diminished reserve capacity could be part of the explanation as to why some Fontan patients develop late-onset lymphatic complications.

UR - http://www.scopus.com/inward/record.url?scp=85107252965&partnerID=8YFLogxK

U2 - 10.14814/phy2.14862

DO - 10.14814/phy2.14862

M3 - Journal article

C2 - 34057301

VL - 9

SP - e14862

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 11

M1 - e14862

ER -

ID: 68336470