Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

FSHB and FSHR gene variants exert mild modulatory effect on reproductive hormone levels and testis size but not on semen quality: A study of 2,020 men from the general Danish population

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Semen quality and waiting time to pregnancy explored using association mining

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Impact of psychological stress measured in three different scales on testis function: A cross-sectional study of 1362 young men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Testicular microlithiasis on scrotal ultrasound in 4850 young men from the general population: associations with semen quality

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. 'Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway'

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Breast cancer rate after oophorectomy: A Prospective Danish Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Har industrialiseringen ødelagt vores fertilitet?

    Publikation: Bidrag til tidsskriftTidsskriftartikelFormidling

  3. Prenatal exposure to maternal stressful life events and earlier age at menarche: the Raine Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Prenatal Exposure to Butyl Paraben Is Associated With Fat Percentage in 7-Year-Old Boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Serum insulin-like factor 3 levels are reduced in former androgen users suggesting impaired Leydig cell capacity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Spermatogenesis depends on stimulation by follicle-stimulating hormone (FSH) which binds to FSH receptors (FSHR) on testicular Sertoli cells. Three FSH-related single nucleotide polymorphisms (SNPs); FSHB -211G>T (rs10835638), FSHR -29G>A (rs1394205) and FSHR 2039A>G (rs6166) affect FSH action, and have been suggested to affect testicular function, but the evidence is uncertain.

OBJECTIVE: To describe the associations between the three SNPs and testicular function in a large and well-characterised cohort of men from the general population.

MATERIALS AND METHODS: A cross-sectional study of 2,020 Danish men unselected regarding testicular function. Outcome variables were semen parameters, reproductive hormones and testis size. Genotyping was done by competitive allele-specific quantitative PCR. Differences in genotype frequencies were tested by Chi-square test and associations between genotypes and outcomes were assessed by multivariate linear regressions.

RESULTS: The SNPs affected serum FSH; carriers of the variant affecting FSH secretion (FSHB -211G>T) had lower FSH levels while carriers of variants affecting receptor expression (FSHR -29G>A) and receptor sensitivity (FSHR 2039A>G) had higher FSH levels. Carriers of FSHB -211G>T had lower calculated free-Testosterone/LH ratio. Although both FSHB -211G>T and FSHR 2039A>G were associated with smaller testis size, no clear association was detected in relation to any semen parameters, except a lower total number of morphologically normal spermatozoa in the heterozygous carriers of the FSHB -211G>T DISCUSSION AND CONCLUSION: The studied polymorphisms have only minor modulating influence on testis size and function in healthy men. We detected subtle effects of the three SNPs on FSH levels, but also effects of FSHB -211G>T on calculated free-Testosterone/LH ratio, compatible with altered Leydig cell function. Thus, the role of these FSH-related polymorphisms is complex and modest in men with normal testicular function, but the possible importance of FSH polymorphisms in men with impaired testicular function should be evaluated in future studies in more detail.

OriginalsprogEngelsk
TidsskriftAndrology
Vol/bind9
Udgave nummer2
Sider (fra-til)618-631
Antal sider14
ISSN2047-2919
DOI
StatusUdgivet - mar. 2021

ID: 61840202