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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Forming and ending marital or cohabiting relationships in a Danish population-based cohort of individuals with neurofibromatosis 1

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Trille Kristina Kjaer
  • Elisabeth Wreford Andersen
  • Maja Olsen
  • Line Kenborg
  • Pernille Envold Bidstrup
  • Karoline Doser
  • Hanne Hove
  • John R Østergaard
  • Christoffer Johansen
  • Sven Asger Sørensen
  • John J Mulvihill
  • Jeanette F Winther
  • Susanne Oksbjerg Dalton
Vis graf over relationer

Individuals with neurofibromatosis 1 (NF1) may have problems in managing the transition between childhood and adulthood, such as forming a relationship or finding a partner. We aimed to determine the association between NF1 and forming and ending marital or cohabiting relationships by comparing a large Danish population of adults with NF1 with population comparisons. In this population-based cohort study, we compared a population of Danish adults who were hospitalized for or with complications to prior diagnosed NF1 (n = 787) with population comparisons matched on gender and birth year (n = 7787) through nationwide registries with annually updated information on marriage and cohabitation. Discrete-time survival models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the formation and termination of relationships, with adjustment for birth year, gender, and somatic and psychiatric comorbidities at entry. Individuals with NF1 were significantly less likely to form a relationship (HR = 0.65; 95% CI: 0.58-0.73), with the lowest association for individuals ≥33 years (HR 0.40; 95% CI: 0.25-0.63) and the highest for those aged 18-20 years (HR 0.82; 95% CI: 0.70-0.96). No significant difference was found for ending relationships (HR 1.00; 95% CI: 0.86-1.16). In conclusion, individuals who were hospitalized for NF1 are less likely to engage in marital or cohabiting relationships than population comparisons and are older when they form their first relationship. Once a relationship has been established, however, couples with a NF1-individual are not at greater risk of ending the relationship.

OriginalsprogEngelsk
TidsskriftEuropean journal of human genetics : EJHG
Vol/bind28
Udgave nummer8
Sider (fra-til)1028-1033
Antal sider6
ISSN1018-4813
DOI
StatusUdgivet - aug. 2020

ID: 61822723