Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049)

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Phenotypic and genotypic features of a large kindred with a germline AIP variant

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Insulin sensitivity in relation to fat distribution and plasma adipocytokines among abusers of anabolic androgenic steroids

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. ACTH stimulation test in patients with type 1 diabetes and recurrent severe hypoglycaemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelFormidling

  4. Revised criteria for PCOS in WHO Group II anovulatory infertility - a revival of hypothalamic amenorrhoea?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Sex-specific estrogen levels and reference intervals from infancy to late adulthood determined by LC-MS/MS

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Ovarian reserve markers in women using various hormonal contraceptives

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Ovarian cortical follicle density in infertile women with low anti-Müllerian hormone

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Ernesto Bosch
  • Anders Nyboe Andersen
  • Pedro Barri
  • Juan Antonio García-Velasco
  • Petra de Sutter
  • Manuel Fernández-Sánchez
  • Hana Visnova
  • Bjarke M Klein
  • Bernadette Mannaerts
  • Joan-Carles Arce
Vis graf over relationer

OBJECTIVE: To study the association between serum anti-Müllerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5·2-12·1μg/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a GnRH antagonist protocol.

DESIGN: Secondary analysis of a randomized controlled trial with stratified randomization according to AMH (lower stratum: 5·0-14·9 pmol/l; higher stratum: 15·0-44·9 pmol/l).

PATIENTS: Infertile women of good prognosis (n = 265).

MEASUREMENTS: Follicular development and endocrine parameters during controlled ovarian stimulation (COS) with rhFSH.

RESULTS: Serum FSH levels increased with increasing rhFSH doses and steady-state levels for each dose were similar in both AMH strata. In the whole study population, significant (P < 0·001) positive dose responses were observed for the number of follicles ≥12 mm, and serum levels of oestradiol, inhibin B, inhibin A and progesterone at end of stimulation. In comparison with the higher AMH stratum, patients in the lower AMH stratum had significantly different slopes of the dose-response curves for these hormones, and no clear dose-related increase was observed for the number of follicles in these patients.

CONCLUSIONS: Dose-response relationships between rhFSH and follicular development and endocrine parameters are significantly different for IVF/ICSI patients with lower and higher serum AMH levels at start of COS.

OriginalsprogEngelsk
TidsskriftClinical Endocrinology
Vol/bind83
Udgave nummer6
Sider (fra-til)902-12
Antal sider11
ISSN0300-0664
DOI
StatusUdgivet - dec. 2015

ID: 46177912