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Fibrinogen: A potential biomarker for predicting disease severity in multiple sclerosis

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@article{7c49e561ec834939ba5f837ea17c2fad,
title = "Fibrinogen: A potential biomarker for predicting disease severity in multiple sclerosis",
abstract = "BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The exact pathogenesis behind the development of MS is unknown. This study aims to elucidate the role of fibrinogen in MS pathology and discuss candidacy as a biomarker for disease management.METHOD: The method applied is a systematic literature review on the bio-medical database PubMed.RESULTS: This study found that even though the role of fibrinogen in disease development has been studied considerably, clinical application as a viable biomarker has not yet been achieved conclusively in human studies.CONCLUSION: Recent evidence points toward fibrinogen and its degradation products playing a possible role in the disease pathogenesis Further research is needed to convincingly evaluate fibrinogen as a practical biomarker for diagnostic use or for assessing disease severity.",
keywords = "Fibrinogen, Fibrin, Multiple sclerosis, Blood, Cerebrospinal fluid, Diagnosis, Therapeutic use, Prognostic use, Immunology",
author = "Usman Ahmad and Frederiksen, {Jette Lautrup}",
note = "Copyright {\textcopyright} 2020 Elsevier B.V. All rights reserved.",
year = "2020",
month = nov,
doi = "10.1016/j.msard.2020.102509",
language = "English",
volume = "46",
pages = "102509",
journal = "Multiple Sclerosis and Related Disorders",
issn = "2211-0348",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Fibrinogen

T2 - A potential biomarker for predicting disease severity in multiple sclerosis

AU - Ahmad, Usman

AU - Frederiksen, Jette Lautrup

N1 - Copyright © 2020 Elsevier B.V. All rights reserved.

PY - 2020/11

Y1 - 2020/11

N2 - BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The exact pathogenesis behind the development of MS is unknown. This study aims to elucidate the role of fibrinogen in MS pathology and discuss candidacy as a biomarker for disease management.METHOD: The method applied is a systematic literature review on the bio-medical database PubMed.RESULTS: This study found that even though the role of fibrinogen in disease development has been studied considerably, clinical application as a viable biomarker has not yet been achieved conclusively in human studies.CONCLUSION: Recent evidence points toward fibrinogen and its degradation products playing a possible role in the disease pathogenesis Further research is needed to convincingly evaluate fibrinogen as a practical biomarker for diagnostic use or for assessing disease severity.

AB - BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The exact pathogenesis behind the development of MS is unknown. This study aims to elucidate the role of fibrinogen in MS pathology and discuss candidacy as a biomarker for disease management.METHOD: The method applied is a systematic literature review on the bio-medical database PubMed.RESULTS: This study found that even though the role of fibrinogen in disease development has been studied considerably, clinical application as a viable biomarker has not yet been achieved conclusively in human studies.CONCLUSION: Recent evidence points toward fibrinogen and its degradation products playing a possible role in the disease pathogenesis Further research is needed to convincingly evaluate fibrinogen as a practical biomarker for diagnostic use or for assessing disease severity.

KW - Fibrinogen

KW - Fibrin

KW - Multiple sclerosis

KW - Blood

KW - Cerebrospinal fluid

KW - Diagnosis

KW - Therapeutic use

KW - Prognostic use

KW - Immunology

U2 - 10.1016/j.msard.2020.102509

DO - 10.1016/j.msard.2020.102509

M3 - Review

C2 - 32977072

VL - 46

SP - 102509

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

SN - 2211-0348

ER -

ID: 61514545